满药复方木鸡颗粒抗菌和抗癌活性研究

为探索满药复方木鸡颗粒可能具有的其他药理作用,采用琼脂平板打孔法对满药复方木鸡颗粒对金黄色葡萄球菌、大肠埃希氏菌、鼠伤寒沙门氏菌、副溶血弧菌、白色念珠菌5种致病菌的抑菌活性进行研究,用MTT法研究其对结肠癌细胞HT-29的抑制作用。结果表明:复方木鸡颗粒对金黄色葡萄球菌、副溶血弧菌、白色念珠菌均具有抑制作用,质量浓度为0.2 mg·mL^-1的样品对三种菌的抑菌圈分别为26.29、24.52和25.13 mm;质量浓度为0.2 mg·mL^-1的样品对结肠癌细胞HT-29有较明显的抑制作用,培养72 h后,生长抑制率可达到85.52%。为满药复方木鸡颗粒功能的进一步研究补充了数据。

Antibacterial and Anticancer Activities of Manchu Medicine Compound Muji Granule

In order to explore other pharmacological effects of Manchu medicine compound Muji granule, the antibacterial activity of compound Muji granule against 5 pathogenic bacteria including Staphylococcus aureus, Escherichia coli, Salmonella typhimurium, Vibrio parahaemolyticu and Candida albicans was studied using agar well diffusion method. Furthermore, the anticancer activity on colon cancer cell HT-29 was assayed by MTT assay. The results indicated that 0.2 mg·mL^-1 compound Muji granule showed antibacterial activities against Staphylococcus aureus, Vibrio parahaemolyticu and Candida albicans. The average diameters of the inhibition zones were 26.29 mm, 24.52 mm, and 25.13 mm, respectively. 0.2 mg·mL^-1 compound Muji granule could significantly inhibit the growth of colon cancer cell HT-29. The growth inhibition rate reached 85.52% after incubated for 72h. The data further supplemented the functional study of Manchu medicine compound Muji granule.