| 低聚壳聚糖金属卟啉络合物的制备及抗肿瘤细胞活性研究 |
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| 引用本文： | 李岩,谢云涛,何玉凤,王荣民,丁兰.低聚壳聚糖金属卟啉络合物的制备及抗肿瘤细胞活性研究[J].西北师范大学学报,2007,43(2):50-52,56. |
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| 作者姓名： | 李岩 谢云涛 何玉凤 王荣民 丁兰 |
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| 作者单位： | [1]西北师范大学甘肃省高分子材料重点实验室,甘肃兰州730070 [2]西北师范大学生命科学学院,甘肃兰州730070 |
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| 基金项目： | 国家自然科学基金;甘肃省自然科学基金 |
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| 摘 要： | 制备了低聚壳聚糖金属（铜、钴）卟啉络合物,通过紫外-可见光谱和红外光谱对其进行了表征,采用SRB细胞染色法研究了低聚壳聚糖金属（铜、钴）卟啉络合物对人体肝癌细胞Bel-7721的毒活性.结果表明,系列化合物均对肝癌细胞Bel-7402有较强的抑制生长活性,IC50值均小于100μg/mL,在10~30μg/mL范围内,是一类具有应用前景的抗肿瘤药物前体.
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| 关 键 词： | 卟啉 低聚壳聚糖 金属卟啉络合物 抗肿瘤细胞活性 |
| 文章编号： | 1001-988X（2007）02-0050-03 |
| 修稿时间： | 2006-10-092006-12-21 |
Preparation and anticancer activity of chitooligosaccharide porphyrins metallic complexes |
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| LI Yan,XIE Yun-tao,HE Yu-feng,WANG Rong-min,DING Lan.Preparation and anticancer activity of chitooligosaccharide porphyrins metallic complexes[J].Journal of Northwest Normal University Natural Science (Bimonthly),2007,43(2):50-52,56. |
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| Authors: | LI Yan XIE Yun-tao HE Yu-feng WANG Rong-min DING Lan |
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| Institution: | 1. Key Laboratory of Polymer Materials of Gansu Province, Northwest Normal University, Lanzhou 730070, Gansu, China; 2. College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, China |
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| Abstract: | Water soluble metal porphyrin complexes(MTAPP,M=Cu,Co) are conjugated to chitooligosaccharide(COS),and characterized by infrared spectra and ultraviolet-visible spectrometry.Their bioactivities are studied by SRB method.Bioassay results show that the COS supported metal porphyrin complexes possess high antitumor activity against liver cancer cell in vitro. |
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| Keywords: | porphyrin chitooligosaccharide metallic complexes of porphyrin anticancer activity |
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