首页 | 本学科首页   官方微博 | 高级检索  
     检索      

复方肿瘤血管生成抑制因子口服液的一般毒性和遗传毒理研究
引用本文:向华,杨保胜,丰慧根,孙璐,李永辉,徐存拴.复方肿瘤血管生成抑制因子口服液的一般毒性和遗传毒理研究[J].河南师范大学学报(自然科学版),1999,27(1):73-76.
作者姓名:向华  杨保胜  丰慧根  孙璐  李永辉  徐存拴
作者单位:1. 河南师范大学生物系
2. 新乡医学院细胞生物学教研室
基金项目:河南省杰出青年科学基金
摘    要:为了探讨复方肿瘤血管生成抑制因子口服液(COL-TAI)对动物及人体的一般毒性和遗传毒性,采用动物急性毒性试验、动物慢性毒性试验、小鼠骨髓嗜多染红细胞微核实验和人体外周血淋巴细胞体外培养染色体畸变实验,观察COL-TAI的一般毒性和遗传毒性.结果显示:COL-TAI对小鼠的急性毒性试验表明,该药口服途径的LD50为9.1201gkg-1(7.766g~10.7091gkg-1);慢性毒性试验显示该口服液对内脏各器官和生理指标均无任何蓄积毒性和延迟毒性反应作用;COL-TAI对小鼠骨髓微核和人外周血淋巴细胞染色体畸变等均无诱变作用,COL-TAI可降低环磷酰胺(CTX)对受试动物细胞微核的发生率.COL-TAI无毒,对化学法突变剂引起的微核产生有抑制作用,对染色体损伤有一定的保护作用.

关 键 词:血管生成抑制因子  毒性试验  畸变  微核
修稿时间:1998-08-30

A Study on the General Toxicity and Genotoxicity of Compound Oral Liquid of Tumor Angiogenesis Inhibitor
Xiang Hua Yang Baosheng,a Feng Huigen,a et al.A Study on the General Toxicity and Genotoxicity of Compound Oral Liquid of Tumor Angiogenesis Inhibitor[J].Journal of Henan Normal University(Natural Science),1999,27(1):73-76.
Authors:Xiang Hua Yang Baosheng  a Feng Huigen  a
Abstract:To research the general toxicity and genotoxicity of compoand oral liquid of Tumor Angiogenesis inhibitor (COL-TAI)on experimental animal and human, cute and chronic toxicity in rice,bone marrowmicronucleus text in mice and lymphocyte chromosomal aberration text in human beings were determined. The results showed that acute toxicitial test results show that this oral liquid's LD50 were 9.1201g·kg -1 , chronic toxicitial test show that it had no toxicity. Genotoxitial test results show that this oral liquid did not raise eighter rate of micronucleus orchromosomal aberration. It could reduce the rate of mocronucleus was induced by CTX and chromosomal aberration. COL-TAI has no general toxicity and genotoxicity,It could reduced the rate of chromosomal aberration.
Keywords:angiogenesis inhibitor  mocronucleus  chromosomal aberration  enotoxicity
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号