头孢呋辛酯在丙酮溶液中的降解动力学研究

为了研究头孢呋辛酯丙酮溶液的稳定性,应用高效液相色谱,采用单因素方式考察初始溶液pH值、温度、氧化剂种类等条件下,头孢呋辛酯在溶液中的含量随时间的变化规律,依据化学反应动力学方法建立得到了头孢呋辛酯在不同条件下的降解反应动力学模型,回归得到了模型参数、预测半衰期(t_(1/2))。利用Materials Studio模拟软件从分子尺度对头孢呋辛酯的降解机理进行了分析。结果表明:头孢呋辛酯丙酮溶液的降解符合一级反应动力学;pH值9.54时头孢呋辛酯丙酮溶液基本稳定,pH值≥9.54时其化学稳定性变差,随着pH值的增大降解速率迅速加快、溶液颜色加深;头孢呋辛酯丙酮溶液的化学稳定性随温度的升高而变差。研究结果可为相关产品的生产过程、结晶工艺设计、存储和应用提供数据支撑。

Study of Kinetics of degradation of cefuroxime axetil in acetone solution

In order to study the stability of cefuroxime axetil acetone solution, by using high-performance liquid chromatography, the single factor test was conducted to study the variation ofcefuroxime axetilcontent in the solution with time under different conditions such as the initial solution pH, temperature and oxidant species. The chemical reaction kinetics method was used to establish the degradation reaction kinetics models of cefuroxime axetil under different conditions. The model parameters were obtained by regression, and the half-life(t1/2) was predicted. The degradation mechanism of cefuroxime axetil was analyzed from the molecular scale by Materials Studio simulation software. The results show that the degradation of cefuroxime axetil acetone solution under the above conditions is in line with the first-order reaction kinetics. When pH is lower than 9.54, cefuroxime axetil acetone solution is basically stable. When pH is higher than 9.54, the chemical stability of cefuroxime axetil acetone solution becomes worse, the degradation rate increases rapidly, and the color of the solution becomes darker with the increase of pH value. The chemical stability of cefuroxime axetil acetone solution decreases with the increase of temperature. The research result provides data support for production process, crystallization process design, storage and application.