| UV法测定替硝唑缓释片剂的释药特性 |
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| 引用本文： | 马慧丽,姚军,王琳,左海燕,滑明丽.UV法测定替硝唑缓释片剂的释药特性[J].河北科技大学学报,2005,26(4):289-291. |
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| 作者姓名： | 马慧丽 姚军 王琳 左海燕 滑明丽 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄,050018 |
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| 基金项目： | 国家人事部基金资助项目([2004]99)，河北省教育厅基金资助项目(2004423) |
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| 摘 要： | 为了采用紫外分光光度(UV)法测定替硝唑(tinidazole)-聚癸二酸酐缓释片剂的含量,并研究其释药特性,利用替硝唑在317 nm处有最大吸收、空白辅料无干扰进行研究,结果发现替硝唑质量浓度在5.0~100.0μg.mL-1范围内,含量与吸光度之间线性关系良好(r=0.999 68);样品的平均回收率为(99.94±1.54)%,RSD为1.54%(n=3)。释药结果表明,聚癸二酸酐对替硝唑的释放均呈一级释放动力学特征,回归系数R为96.2%,回归结果为Y=9.102 92+34.959 58t-3.274 58t2。结果表明该方法灵敏、专属、准确、操作简便,可用于替硝唑缓释片剂的含量测定。
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| 关 键 词： | 替硝唑 紫外分光光度法 缓释 含量测定 |
| 文章编号： | 1008-1542(2005)04-0289-03 |
| 修稿时间： | 2005年9月7日 |
Drug release characteristics of tinidazole tablets determinated by UV |
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| MA Hui-li,YAO Jun,WANG Lin,ZUO Hai-yan and HUA Ming-li.Drug release characteristics of tinidazole tablets determinated by UV[J].Journal of Hebei University of Science and Technology,2005,26(4):289-291. |
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| Authors: | MA Hui-li YAO Jun WANG Lin ZUO Hai-yan and HUA Ming-li |
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| Institution: | College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China;College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China |
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| Abstract: | This is to develop a UV method for the determination of tinidazole-poly(sebacic anhydride) tablets,and study the drug release characteristic of the tablets.Because tinidazole was determined at 317nm and blank supplements had little interference,it is found that the calibration curve was linear(r=0.999 68) in the range of 5.0~100.0 μg·mL~(-1) for tinidazole,the mean recovery being((99.94)±1.54)%,with RSD of 1.54%(n=3) .The results of drug release demonstrated that the tinidazole-poly(sebacic anhydride) tablets followed first order release kinetics,the regression parameter was 96.2%,the regression equation was Y=9.102 92+34.959 58 t-3.274 58 t~2.As a result,it indicated that the method is sensitive,specific,accurate, simple and suitable for the determination of tinidazole preparations. |
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| Keywords: | tinidazole UV-spectrophotometry slow-releasing content determination |
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