| 钼暴露对雌性小鼠胚胎体内发育的影响 |
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| 引用本文： | 张玉玲,白玉涛,刘凤军,张才,陈晓丽,杨自军.钼暴露对雌性小鼠胚胎体内发育的影响[J].河南科技大学学报(自然科学版),2011,32(5):50-52,59,3. |
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| 作者姓名： | 张玉玲 白玉涛 刘凤军 张才 陈晓丽 杨自军 |
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| 作者单位： | 1. 河南科技大学动物科技学院,河南洛阳,471003
2. 轮台县草原站,新疆轮台,841600 |
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| 基金项目： | 国家自然科学基金项目(31040081) |
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| 摘 要： | 为了探索钼对雌性动物生殖性能的影响,以雌雄ICR小鼠为实验动物,通过在饮水中添加不同剂量的钼酸钠,建立钼暴露模型:对照组(饮蒸馏水)、低钼组(200 mg/L)、中钼组(400 mg/L)、高钼组(600 mg/L)。在染毒30 d时,与正常雄鼠交配,第3.5 d观察胚胎发育情况,第5.5 d检测子宫着床情况。结果表明:高钼组和中钼组胚胎发育的正常率显著低于对照组(P<0.05),低钼组差异不明显;高钼组着床率显著低于对照组(P<0.05),中钼组和低钼组差异不显著;钼处理组的平均着床胚泡数均显著低于对照组(P<0.05);此外,钼暴露雌鼠的卵巢及子宫出现了不同程度的淤血和肿胀。可见:钼摄入过量会对胚胎发育、着床及生殖器官形态产生显著不利影响,甚至造成不孕,这可为钼毒理学研究、环境污染造成不孕的研究提供资料。
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| 关 键 词： | 小鼠 钼暴露 胚胎发育 生殖 毒性 |
Effects of Exposure to Mo of Female Mice on Development of Early Embryo in Vivo |
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| ZHANG Yu-Ling,BAI Yu-Tao,LIU Feng-Jun,ZHANG Cai,CHEN Xiao-Li,YANG Zi-Jun.Effects of Exposure to Mo of Female Mice on Development of Early Embryo in Vivo[J].Journal of Henan University of Science & Technology:Natural Science,2011,32(5):50-52,59,3. |
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| Authors: | ZHANG Yu-Ling BAI Yu-Tao LIU Feng-Jun ZHANG Cai CHEN Xiao-Li YANG Zi-Jun |
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| Institution: | ZHANG Yu-Ling1,BAI Yu-Tao2,LIU Feng-Jun1,ZHANG Cai1,CHEN Xiao-Li1,YANG Zi-Jun1(1.Animal Science & Technology School,Henan University of Science & Technology,Luoyang 471003,China,2.Luntai Grassland Station,Korla 841600,China) |
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| Abstract: | In order to explore the effect of molybdenum(Mo) on reproduction ability of female animals,this paper investigated the situation of early embryonic development of female mice poisoned by respectively adding the 0(control),200,400,600 milligram sodium molybdate to their per litre drinking water for 30 days.Mated with normal males,the development of embryos was observed on day 3.5 after mating,and implantation was detected on day 5.5.Compared with the control,the normal rate of embryo in the treatment of 400 ... |
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| Keywords: | Mouse Molybdenum exposure Embryonic development Reproduction Toxicity |
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