| 多孔羟基磷灰石纳米颗粒的制备与缓释性能 |
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| 引用本文： | 李宾杰,薄新党,马远方.多孔羟基磷灰石纳米颗粒的制备与缓释性能[J].新乡学院学报(自然科学版),2011(3):230-233. |
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| 作者姓名： | 李宾杰 薄新党 马远方 |
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| 作者单位： | 河南大学医学院免疫学研究所;河南化工职业学院化学工程系 |
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| 基金项目： | 河南省重点科技攻关项目(092102310158) |
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| 摘 要： | 在碱性条件下,分别以Ca（NO3）2、P2O5为钙源和磷源,以水-乙醇混合溶液为反应介质,采用水热/溶剂热法合成多孔羟基磷灰石（HA）纳米颗粒。通过透射电镜（TEM）、X-线衍射仪（XRD）及傅里叶红外光谱仪（FT-IR）表征、分析了其形貌和组成。用紫外分光光度法（UV-SP）考查了盐酸阿霉素药物在多孔羟基磷灰石纳米颗粒上的吸附和脱附行为,二者均表现出先快后慢再快的特点,说明多孔羟基磷灰石纳米颗粒作为药物载体有着很好的应用前景。
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| 关 键 词： | 多孔羟基磷灰石纳米颗粒 盐酸阿霉素 吸脱附行为 药物载体 |
Preparation of Porous Hydroxyapatite Nanoparticles and Its Slow-release Property |
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| Authors: | LI Bin-jie BO Xin-dang MA Yuan-fang |
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| Institution: | 1(1.Institute of Immunology of Medical College,Henan University,Kaifeng 475004,China; 2.Department of Chemical Eingeering,Henan Chemical Industry Vocational College,Zhengzhou 450042,China) |
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| Abstract: | Calcium nitrate（Ca（NO3）2） and diphosphorus pentoxide（P2O5） as reactants,porous hydroxyapatite（HA） nanoparticles was synthesized in the basic water-ethanol solution by hydro/solvent thermal method.The morphology and the composition of HA were characterized by transmission electron microscope（TEM）,X-ray diffraction（XRD） and Fourier transform infrared spectroscopy（FT-IR）.Furthermore,the adsorption-desorption behavior of chemotherapy doxorubicin hydrochloride on porous HA nanoparticles was studied by ultraviolet spectrophotometry（UV-SP）,which shows the steps of quick-slow-quick.Compared with commom nanoparticles,the porous HA nanoparticles demonstrate distinct applications in drug carrier. |
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| Keywords: | porous hydroxyapatite nanoparticles doxorubicin hydrochloride adsorption-desorpation behavior drug carrier |
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