| 毛细管电泳法分离3种卡因类药物 |
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| 引用本文： | 王精明,范瑞芳.毛细管电泳法分离3种卡因类药物[J].华南师范大学学报(自然科学版),2001(3):103-106. |
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| 作者姓名： | 王精明 范瑞芳 |
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| 作者单位： | 1. 惠州大学生物学系,
2. 华南师范大学生物学系, |
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| 摘 要： | 运用毛细管区带电泳技术，对布比卡因、利多卡因、普鲁卡因3种药物的分离进行了研究，优化选择pH值、缓冲溶液浓度、温度、电压等实验参数，结果表明，该方法简便，操作易行，适用于制药工业中在线检测及临床检验。
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| 关 键 词： | 布比卡因 利多卡因 普鲁卡因 毛细管电泳 局部麻醉药 药物分离 |
| 文章编号： | 1000-5463(2001)03-0103-04 |
| 修稿时间： | 2001年2月14日 |
THE DRUG SEPARATION OF THREE NARCOTICS BY CAPILLARY ELECTROPHORESIS |
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| WANG Jing - ming,FAN Rui - fang.THE DRUG SEPARATION OF THREE NARCOTICS BY CAPILLARY ELECTROPHORESIS[J].Journal of South China Normal University(Natural Science Edition),2001(3):103-106. |
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| Authors: | WANG Jing - ming FAN Rui - fang |
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| Abstract: | The separation of Novocaine, Lidocaine and Bupivacaine by Capillary Zone Electrophoresis is investigated, and an analysis method for industry production and clinical medical is prpvoded. The buffer system of Tris - H3PO4 was used in the experiment. The effects of pH and ionic strength of buffer on elec-troosmotic flow and resolution were examined. The three drugs could be separated within 22 minutes using 30 mmol/L Tris - H3PO4 buffer (pH 3.5) . It was demonstrated that the method compared with High Performance Liquid Chromatography might be suitable to the separation of the three drugs. |
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| Keywords: | Bupivacaine Lidocaine Novocaine Capillary electrophoresis |
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