溶剂N,N-二甲基甲酰胺参与的Michael加成-消除反应及其反应机理

研究5-烷氧基-3,4-二卤-2(5H)-呋喃酮与2-苯并咪唑的Michael加成-消除反应过程中，发现发生的溶剂N,N-二甲基甲酰胺（DMF）在催化剂无水乙醇钠的作用下参与的串联反应.探讨了反应时间、催化剂用量、反应温度对反应的影响，合成了四个化合物（4a-4d）.通过UV、IR、 1H NMR、13C NMR、MS、元素分析对4a-4d进行结构表征，提出并通过GC-MS验证了可能的反应机理.

THE TANDEM MICHAEL ADDITION-ELIMINATION REACTION OF 5-ALKOXY-3,4-DIHALO-2(5H)-FURANONE WITH SOLVENT DMF AND ITS REACTION MECHANISM

During the research on the tandem Michael addition-elimination reaction of 5-alkoxy-3,4-dihalo-2(5H)-furanone with 2-substituted benzimidazoles, the reaction that the solvent N,N-dimethylformamide (DMF) participated in was witnessed as an unexpected result. Based on the discussions of the synthetic conditions, such as reaction time, catalyst dosage, and reaction temperature, four compounds (4a-4d), including two novel compounds, were obtained by the reaction of 5-alkoxyl-3,4-dihalo-2(5H)-furanone with DMF in the presence of the catalyst ethanol sodium. The structure of 4a-4d was characterized by UV, IR, 1H NMR, 13C NMR, MS and elemental analysis. A possible reaction mechanism was proposed and confirmed by GC-MS.