| 吉西他滨单药治疗老年晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 孙桂丽,王大鹏.吉西他滨单药治疗老年晚期非小细胞肺癌的临床观察[J].内蒙古民族大学学报(自然科学版),2009,24(2):208-209. |
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| 作者姓名： | 孙桂丽 王大鹏 |
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| 作者单位： | 内蒙古民族大学,附属医院肿瘤科,内蒙古,通辽,028000 |
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| 摘 要： | 目的：观察吉西他滨单药治疗老年晚期非小细胞肺癌（NSCLC）的疗效和毒性反应．方法：对28例NSCLC患者采用罔产吉西他滨1000mg/m^2，静脉注射30min，第1、8天，3～4周重复，2个周期后评价疗效．结果：28例均可评价疗效．总有效率（CR＋PR）为30．6％（11／36），受益反应63．9％（23／36），毒副反应以骨髓抑制为常见．结论：吉西他滨单药治疗老年晚期NSCLC有较好疗效，毒性反应轻，患者易于耐受．
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| 关 键 词： | 非小细胞肺癌 化学治疗 吉西他滨 |
Clinical Observation on the Effect of Gemcitabine Monotherapy in Treating Elderly Patients with Advanced Non - small Cell Lung Cancer |
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| SUN Gui-li,WANG Da-peng.Clinical Observation on the Effect of Gemcitabine Monotherapy in Treating Elderly Patients with Advanced Non - small Cell Lung Cancer[J].Journal of Inner Mongolia University for the Nationalities(Natural Sciences),2009,24(2):208-209. |
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| Authors: | SUN Gui-li WANG Da-peng |
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| Institution: | (Department of Oncology, Affiliated Hospital,Inner Mongolia University for Nationalities, Tongliao 028000,China) |
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| Abstract: | Objective：To evaluate the clinical effects and toxic reactions of gemcitabine monotherapy in the treatment of elderly patients with advanced non - small cell lung cancer （NSCLC）. Methods：28 elderly patients with advanced NSCLC received gemcitabine 1000mg/m^2 intravenously on 1st and 8th day. The chemotherapy was repeated every 3 - 4 weeks. Curative effects and toxicities were evaluated after 2 cycles of chemotherapy. Results：The total effective rate was 30.6% （11/36）. The beneficial response was 63.9% （23/36）. The main toxicities were leucopenia and thrombocytopenia. Conclusion：Cemcitabine is effective, safe and well tolerable in the treatment of elderly patients with advanced NSCLC. It significantly improve the quality of life in patients with NSCLC and prolong their survival time. |
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| Keywords: | Non-small cell lung cancer （NSCLC） Chemotherapy Gemcitabine |
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