| NOS3多态性与高血压继发左心室肥厚的关系 |
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| 引用本文： | 辛颖,奥·乌力吉,宋晓东,刘哲,惠汝太.NOS3多态性与高血压继发左心室肥厚的关系[J].内蒙古民族大学学报(自然科学版),2010,25(1):87-92. |
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| 作者姓名： | 辛颖 奥·乌力吉 宋晓东 刘哲 惠汝太 |
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| 作者单位： | 1. 内蒙古民族大学,蒙医药学院,内蒙古,通辽,028043
2. 北京协和医学院阜外心血管病医院,北京,100037 |
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| 摘 要： | 目的:探讨内皮型一氧化氮合酶基因(NOS3)的第4内含子串联重复序列多态性(eNOS4a/b)与原发性高血压患者左心室肥厚的关系.方法:采取病例对照研究,应用PCR技术对高血压患者(2179人,包括1061名左心室肥厚和1118名左心室非肥厚患者)及正常对照人群(812人)进行基因分型,并经测序验证;用a表示含有4个串联重复序列的基因型,用b表示含有5个串联重复序列的基因型.测量所有病例的超声参数.结果:NOS3的eNOS4a/b基因型频率符合Hardy-Weinberg平衡;a/a、a/b、b/b基因型频率在高血压肥厚、非肥厚患者及正常人群中分布分别为0.7%、12.5%、86.8%;0.5%、10.9%、88.6%和0.6%、12.8%、86.6%.a等位基因频率分别为6.9%、6.0%和7.0%,b等位基因频率分别为93.1%、94.0%和93.1%.各基因型频率与等位基因频率在三组之间无统计学差异(P>0.05).携带不同基因型的患者的临床指标和超声参数均无差异(P>0.05).结论:本研究认为NOS3的eNOS4a/b并不增加高血压继发左心室肥厚的易感性.
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| 关 键 词： | 内皮型一氧化氮合酶 心血管疾病 基因多态性 高血压 左心室肥厚 |
Association of Polymorphism of Endothelial Nitric Oxide Synthase Gene with Left Ventricular Hypertrophy in Hypertensive Patient |
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| XIN Ying,AO.Wuliji,SONG Xiao-dong,LIU Zhe,HUI Ru-tai.Association of Polymorphism of Endothelial Nitric Oxide Synthase Gene with Left Ventricular Hypertrophy in Hypertensive Patient[J].Journal of Inner Mongolia University for the Nationalities(Natural Sciences),2010,25(1):87-92. |
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| Authors: | XIN Ying AOWuliji SONG Xiao-dong LIU Zhe HUI Ru-tai |
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| Institution: | 1.College of Mongolian Medicine and Pharmacy/a>;Inner Mongolia University for Nationalities/a>;Tongliao 028043/a>;China/a>;2.Sino-German Laboratory for Molecular Medicine/a>;FuWai Hospital/a>;Chinese Academy of Medical Sciences and Peking Union Medical College/a>;Beijng 100037/a>;China |
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| Abstract: | Objective:We conducted a study to investigate for possible associations in eNOS gene(NOS3)intron 4 VNTR polymorphism with cardiac hypertrophy in hypertensive patients,and investigated whether eNOS4a/b polymorphism are associated with an increased risk of left ventricular hypertrophy in hypertension.Methods:We performed a case-control study involving 2179 Chinese hypertensive patients,including 1061 with LVH(left ventricular hypertrophy) and 1118 without LVH,and 812 controls.The polymorphism of eNOS4a/b in t... |
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| Keywords: | Endothelial NO synthase Cardiovascular disease Gene polymorphism Hypertension Left ventricular hypertrophy |
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