蒙药敖其日奈日勒嘎治疗类风湿关节炎的临床研究

目的：通过临床试验研究,客观评价蒙药敖其日奈日勒嘎治疗类风湿关节炎的临床研究.方法：将72例类风湿关节炎患者随机分为治疗组和对照组,治疗组用MTX＋蒙药敖其日奈日勒嘎治疗,对照组用MTX治疗.治疗中观察临床症状、体征和试验前后各行一次手的正位片（治疗前）检查以及血常规、肝功能、肾功能检查.结果：（1）治疗组的显效率为6.06%,总有效率为90.91%,对照组显效率为0%,总有效率为81.82%,两组间无显著性差异（P〉0.05）（.2）两组的生化检查结果的改变,两组无显著差异（P〉0.05）,但治疗前后自身对照,两组的RF有显著差异（P〈0.01）,治疗组CRP有显著差异（P〈0.01）,两组的ESR两组无显著差异（P〉0.05）,对照组CRP两组无显著差异（P〉0.05）（.3）对照两组治疗后各症侯好转情况：治疗前后每组各症侯自身对照疼痛程度,压痛程度,晨僵时间P〉0.05两组无显著差异,晨僵,关节屈伸不利等症状的好转（P〈0.05）有显著差异,肿胀程度、肿胀数、压痛数等症状的好转,治疗组优于对照组（P〈0.01）（.4）敖其日奈日勒嘎对人体血象、肝肾功能无明显不良反应.结论：蒙药敖其日奈日勒嘎对类风湿关节炎的治疗有效,两组的总有效率相仿,但治疗晨僵、关节屈伸不利、肿胀程度、肿胀数、压痛数等症状方面蒙药敖其日奈日勒嘎＋MTX组优于MTX组.

Clinical Research of Mongolian Medicine Aoqirinailega in Treatment of Rheumatoid Arthritis

Objective： To objective evaluate the clinical effect of Mongolian medicine Aoqirinailega in treatment of rheumatoid arthritis through clinical trials.Methods： 72 cases of rheumatoid arthritis were randomly divided into treatment group and control group.The treatment group were treated with methotrexate（MTX） ＋ Mongolian medicine Aoqirinailega,the control group were treated with MTX,observing the symptoms and signs during treatment,detecting the hand anterioposterior films,routine blood test,liver function and kidney function before and after treatment.Results： ① The effective rate of treatment group was 6.06%,the total effective rate was 90.91%.The effective rate of control group was 0%,the total effective rate was 81.82%,between the two groups there were no significant difference（P0.05）.② The changes of biochemical test between the two groups had no significant difference（P0.05）,but for the self-contrast before and after treatment,the RF in both groups had significant difference（P0.01）,the CRP in treatment group had significant difference（P0.01）,the ESR in both groups had no significant difference（P0.05）,the CRP of control group had no significant difference（P0.05）.③ Comparaing thesymptom improvement of the two groups after treatment： the pain degree,tenderness level,morning stiffness time of self-contrast in each group had no significant difference before and after treatment（P0.05）,the improvement of morning stiffness and joint flexion and extension dysfunction had significant difference（P0.05）.The swelling degree,swelling number and tenderness number improvement in treatment group were more than that of control group（P0.01）.④Aoqirinailega had no significant adverse reactions on human blood,liver and kidney function.Conclusion： Mongolian medicine Aoqirinailega has an effect in treatment of rheumatoid arthritis,the total effective rate of the two groups are similar,but for treatment of morning stiffness,joint flexion and extension dysfunction,swelling degree,swelling number and tenderness number,Mongolian Aoqirinailega ＋ MTX group is better than than the MTX group.