注射用盐酸多沙普仑联合纳络酮治疗肺性脑病62例疗效观察

目的：探讨注射用盐酸多沙普仑联合纳络酮治疗肺性脑病的疗效及安全性.方法：将入选94例病例随机分为治疗组及对照组,两组均予以抗感染、持续低流量吸氧、解痉平喘、止咳化痰、保持呼吸道通畅、维持酸碱、水、电解质平衡、营养支持等综合治疗.治疗组在此基础上加用盐酸多沙普伦联合纳络酮治疗.结果：治疗组病死率33.87%,对照组病死率56.25%%,两组对比差异有显著性（P〈0.01）.治疗过程中无不良反应发生.结论：注射用盐酸多沙普仑联合纳络酮治疗肺性脑病效确切、安全.

Observation on the Therapeutic Effect of the Combined Application of Doxapram Hydrochloride for Injection and Naloxone to Treat 62 Cases of Pulmonary Encephalopathy

Objective：To investigte the clinical efficacy and safety of combined application of doxapram hydrochloride for injection and naloxone to treat pulmonary encephalopathy.Methods：94 cases were randomly divided into treatment group and control group,Both groups were given the comprehensive treatment including：anti-infection and sustained low-flow oxygen,antispasmodic asthma,relieving cough and eliminating phlegm,keeping fluency of respiratory tract,maintaining the balance of pH,water and electrolyte,supporting nutrition.On that basis,the treatment group plused the combined treatment of doxapram hydrochloride and naloxone.Results：The mortality of treatment group was 33.87%,the mortality of control group was 56.25%,compared the two groups there was a significant difference（P〈0.01）.The course of treatment without adverse reactions.Conclusion：This method has significant efficacy and safety to treat pulmonary encephalopathy.