黑质注射鱼藤酮对大鼠行为和丘脑VL核自发放电的影响

研究中脑黑质注射鱼藤酮对大鼠行为和丘脑VL核神经元电活动的影响.运用网格、斜板和开阔试验检测大鼠行为改变；微电极记录丘脑VL核神经元自发电活动.鱼藤酮脑内注射28 d后，大鼠在网格上的移动潜伏期明显增长，沿斜板下滑次数显著增多，自主活动减少，而静止性蹲坐时间显著增多；丘脑VL核神经元自发放电频数显著降低，电频谱峰向低频区聚集，Ⅰ型簇状放电型式减少，更多的表现为规律型放电或Ⅱ型簇状放电.结果表明黑质注射鱼藤酮能诱发大鼠出现肌僵直、行动迟缓、震颤等类帕金森病征状，丘脑VL核神经元自发放电活动相应减弱，放电型式有所改变.

Effects of Microinjecting Rotenone into SNc on the Behavior and Spontaneous Discharge of Ventrolateral Thalamus in Rats

The effects of microinjecting rotenone into SNc on the behavior and spontaneous activities of the ventrolateral thalamus neurons in rats were studied. 28 days after the injection of rotenone, both the latency of rats′ moving on vertical grid and the numbers of rats′ sliding down the declined plane significantly increased. The willful movements of animals were significantly decreased, and the time of inactive sitting was significantly increased. The spontaneous discharge rate of the VL neurons significantly decreased. Neurons with type 〖KG-*4〗Ⅰbursting fire decreased, however, the regular fire and type 〖KG-*4〗Ⅱ bursting fire increased. The peaks of the power spectrum of neurons moved to the low frequency area. The results suggest that microinjecting rotenone into SNc could cause symptoms similar to Parkinsonism syndrome such as rigidity, slow moving, and tremor etc. The results also indicate that it also causes the decrease of spontaneous electroactivities of VL neurons and the changes of their firing patterns.