| NR1基因敲除对小鼠前额叶脑区LTP的影响 |
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| 引用本文： | 杨李果,曾庆文,张旭亮,曹晓华.NR1基因敲除对小鼠前额叶脑区LTP的影响[J].华东师范大学学报(自然科学版),2012,2012(1):47-53. |
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| 作者姓名： | 杨李果 曾庆文 张旭亮 曹晓华 |
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| 作者单位： | 华东师范大学脑功能基因组学教育部重点实验室上海市脑功能基因组学重点实验室 |
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| 基金项目： | 国家自然科学基金(31070993) |
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| 摘 要： | 用前脑特异性NR1基因敲除小鼠，采用离体脑片场电位技术，研究了NR1亚基在前额叶脑区突触可塑性中的作用.刺激强度—反应(input-output curve)和双脉冲抑制反应(paired pulse depression, PPD)的结果表明，与同窝对照组小鼠相比，NR1基因敲除小鼠前额叶脑区的基本突触传递无明显变化.采用高频刺激(100 Hz, 1 000 ms ×2, 间隔30 s)在小鼠的前额叶脑区诱导长时程增强(long-term potentiation, LTP)，与对照组小鼠相比，NR1基因敲除小鼠前额叶脑区的LTP明显受损.以上数据提示，NR1亚基在前额叶脑区LTP的诱导中起着重要的作用.
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| 关 键 词： | N-甲基-D-天门冬氨酸受体 前额叶皮层 长时程增强 |
| 收稿时间： | 2011-02-01 |
Long-term potentiation of prefrontal cortex in NRl knockout mice |
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| YANG Li-guo,ZENG Qing-wen,ZHANG Xu-liang,CAO Xiao-hua.Long-term potentiation of prefrontal cortex in NRl knockout mice[J].Journal of East China Normal University(Natural Science),2012,2012(1):47-53. |
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| Authors: | YANG Li-guo ZENG Qing-wen ZHANG Xu-liang CAO Xiao-hua |
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| Institution: | (Key Laboratory of Brain Functional Genomics,Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,East China Normal University,Shanghai 200062,China) |
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| Abstract: | This study investigated the prefrontal synaptic plasticity of forebrain-specific NR1 knockout mice by using the vitro field potential recording technique.The results from the inputoutput and paired pulse depression curves suggest that the basal synaptic transmission is normal in the prefrontal cortex of NR1 knockout mice.Prefrontal long-term potentiation(LTP) induced by high frequency stimulation(two trains of 100 Hz with 1 s duration and 30 s interval) was abolished in slices of NR1 knockout mice.These results indicate that NR1 is critical in the induction of long-term potentiation in prefrontal cortex. |
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| Keywords: | N-methyl-D-aspartic acid receptor prefrontal cortex long-term potentiation |
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