| βCaMKII过量表达损害小鼠海马齿状回区长时程抑制 |
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| 引用本文： | 徐浩,王勃,段燕红,曹晓华.βCaMKII过量表达损害小鼠海马齿状回区长时程抑制[J].华东师范大学学报(自然科学版),2012,2012(1):54-62. |
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| 作者姓名： | 徐浩 王勃 段燕红 曹晓华 |
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| 作者单位： | 华东师范大学脑功能基因组学教育部重点实验室,上海市脑功能基因组学重点实验室,上海200062 |
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| 摘 要： | 采用海马齿状回（dentate gyrus, DG）区域特异性过量表达βCaMKII的蛋白修饰转基因小鼠，通过离体电生理技术，研究了βCaMKII高表达对该区域突触可塑性的影响.与对照组相比，转基因小鼠海马齿状回双脉冲抑制反应（paired-pulse depression, PPD）和颗粒细胞的电压—电流曲线（voltage-current curve）没有发生变化，而该区域的长时程抑制（long-term depression, LTD）明显被减弱.实验结果提示，βCaMKII的过量表达不影响小鼠海马齿状回区的突触前递质释放能力和颗粒细胞的被动属性，但损害其长时程抑制.这为进一步研究βCaMKII在学习记忆和突触可塑性中的作用提供了电生理学依据.
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| 关 键 词： | β钙离子/钙调素依赖的蛋白激酶II 海马齿状回 长时程抑制 |
| 收稿时间： | 2011-02-01 |
βCaMKⅡ overexpression impairs long-term depression in dentate gyrus of mice |
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| XU Hao
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WANG Bo
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DUAN Yan-hong
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CAO Xiao-hua.βCaMKⅡ overexpression impairs long-term depression in dentate gyrus of mice[J].Journal of East China Normal University(Natural Science),2012,2012(1):54-62. |
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| Authors: | XU Hao WANG Bo DUAN Yan-hong CAO Xiao-hua |
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| Institution: | (Key Laboratory of Brain Functional Genomics,Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,East China Normal University,Shanghai 200062,China) |
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| Abstract: | This experiment was designed to investigate the effects of the QCaMKII on the longterm depression(LTD) in dentate gyrus(DG)by using the transgenic mice in which the overexpression of QCaMKII is restricted to the DG area.Compared to the control group,the pairedpulse depression curve and voltage-current response in DG of transgenic mice didn’t change,but the LTD was significantly reduced.These results suggest that overexpression of theβCaMKII may impair the long-term depression without effect on the presynaptic function and passive properties of granule cells in DG area. |
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| Keywords: | βCaMKII dentate gyrus long-term depression |
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