人工沸石:一种微波干法合成2-芳基取代苯并咪唑衍生物的高效催化剂

2-取代苯并咪唑是一类具有重要生物活性的化合物，尽管合成方法早在100多年前就有报道，但有关其新的合成方法至今仍不断有文献报道，最近有文献报道用PPA作缩合剂，微波辐照下合成了这类化合物．但这些方法总有一些不足，比如：污染严重、原料贵，步骤长、反应耗时、多有副反应发生、产率低等等，近年来，沸石的独特催化活性引起了人们的特别关注，同时，微波干法反应也正成为当前研窖的执占．因此裴们科研绸尝试将沸石等矿物裁体作为催化剂，

Artificial Zeolite: An Efficient Catalyst for the Synthesis of 2-Aryl Derivatives of Benzimidazole under Microwave Irradiation

A series of benzimidazoles containing furyl and aryl substituents at C-2 position have been synthesiszed by the reaction of 1,2 ,-phenylenediamine with corresponding carboxylic acids under microwave irradiation without solvent , in which artificial zeolite and catalytic amounts of DMF were used as the catalyst and the energy transfer medium, respectively. With such microwave techniques, the reaction times are remarkably shorted and the products are obtained in higher yields and cleaner reactions with easier workup than compared to conventional heating methods.