| 八珍汤和鸡血藤对环磷酰胺所致小鼠骨髓造血微环境损伤的影响 |
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| 引用本文： | 罗霞,陈东辉,余梦瑶,张春雷,李艳华,陶桓晟,杨志荣.八珍汤和鸡血藤对环磷酰胺所致小鼠骨髓造血微环境损伤的影响[J].四川大学学报(自然科学版),2006,43(2):441-444. |
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| 作者姓名： | 罗霞 陈东辉 余梦瑶 张春雷 李艳华 陶桓晟 杨志荣 |
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| 作者单位： | 1. 四川大学生命科学学院,成都,610064;四川省中医药研究所细胞与分子生物学实验室,成都,610041
2. 四川大学生命科学学院,成都,610064 |
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| 基金项目： | 四川省科技厅资助项目(03JY029-106) |
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| 摘 要： | 用环磷酰胺(Cy)连续3d腹腔注射(50mg/kg),造成小鼠的骨髓损伤模型.造模前3d开始给予药物,并与生理盐水组对照,连续7d.常规病理切片,镜下观察骨髓细胞的形态变化,并计算造血组织容量、脂肪组织容量、血窦容量和巨核细胞数;结果显示模型组与空白组有差异,而八珍汤和鸡血藤组的各种骨髓组织与模型组对比有明显恢复,从计算的骨髓各组织容量也可以得到相同的结果.
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| 关 键 词： | 八珍汤 鸡血藤 骨髓微环境 骨髓组织切片 |
| 文章编号： | 0490-6756（2006）02-0441-04 |
| 收稿时间： | 2005-09-13 |
| 修稿时间： | 2005-09-13 |
Influences of Bazhen Decoction and Spatholobus suberectus on the Bone Marrow Microenvironment Damnified by Cytoxan |
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| LUO Xi,CHONG Dong-hui,YU Meng-yao,ZHANG Chun-lei,LI Yan-hu,TAO Huan-shen and YANG Zhi-rong.Influences of Bazhen Decoction and Spatholobus suberectus on the Bone Marrow Microenvironment Damnified by Cytoxan[J].Journal of Sichuan University (Natural Science Edition),2006,43(2):441-444. |
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| Authors: | LUO Xi CHONG Dong-hui YU Meng-yao ZHANG Chun-lei LI Yan-hu TAO Huan-shen and YANG Zhi-rong |
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| Institution: | College of Life Science; Sichuan University;Molecular and Cellular Lab of Chinese Materia Medica; Sichuan Institute of Chinese Materia Medica,College of Life Science; Sichuan University;,College of Life Science; Sichuan University;,College of Life Science; Sichuan University;,College of Life Science; Sichuan University;,College of Life Science; Sichuan University;,College of Life Science; Sichuan University; |
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| Abstract: | Establish the experimental model of bone microenvironment injured by Cytoxan.Then observe the variety of bone marrow cell from organic slices and calculate the content of hematopoietic tissue,content of fat tissue,content of sinusoid and numbers of MK;It was shown that a distinct difference can be observed between the model group and normal group.Compared to the model group,Bazhen Decoction and Spatholobus suberectus accelerated the reversion of each bone marrow tissue,but the effects were different. |
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| Keywords: | Bazhen decoction Spatholobus suberectus bone marrow microenvironment organic slice |
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