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正常胃肠和癌变胃肠粘膜凝集素受体的研究
引用本文:曾仲奎,王涛,于源, 欧阳钦,王小平.正常胃肠和癌变胃肠粘膜凝集素受体的研究[J].四川大学学报(自然科学版),1994(3).
作者姓名:曾仲奎  王涛  于源  欧阳钦  王小平
作者单位:四川大学生物系,华西医科大学附一院
摘    要:FITC标记的20种凝集素与正常和癌变胃肠组织的石蜡切片进行标记,结果表明,FITC-PNA和FITC-LPL对正常胃体和幽门上皮细胞呈阴性反应;FITC-凝集素与胃癌粘膜细胞反应,以PNA、LPL阳性率最高,与肠癌粘膜细胞反应,则以SML和CKL的阳性率最高。实验揭示了癌变胃肠粘膜与正常胃肠粘膜表面的糖复合物各不相同,导致与凝集素结合反应的强度也不相同。

关 键 词:凝集素,受体,肿瘤细胞受体

ASTUDYONTHELECTINRECEPTORSOFNORMALAND CARCINOMAGASTROENTERICTISSUE
Zeng Zhongkui Wang Tao Yu Yuan.ASTUDYONTHELECTINRECEPTORSOFNORMALAND CARCINOMAGASTROENTERICTISSUE[J].Journal of Sichuan University (Natural Science Edition),1994(3).
Authors:Zeng Zhongkui Wang Tao Yu Yuan
Abstract:Paraffin sections of normal/carcinoma gastroenteric tissue were labled with 20 kinds FITC- lectins. The results are as following :PNA and LPL give negative reaction with normal gastric tissue and pylorusepithelia cells.PNA and LPL give the highest positive rate in the reaction with the mucous cells of gastric caqcer ,and the SML and CKL give highest positive rate in the reaction with the mucous cells of intestinal cancer. These results suggest that the glycoconjugates on carcinoma and normal gastroenteric tissues are different,which lead to their different reactive activity to lectins.
Keywords:lectin  receptor  carcinoma cell receptor
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