| 瑞香狼毒根中抑菌活性成分的研究 |
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| 引用本文： | 龚晓霞,李文娟,欧阳秋,王泓,候太平.瑞香狼毒根中抑菌活性成分的研究[J].四川大学学报(自然科学版),2006,43(3):697-701. |
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| 作者姓名： | 龚晓霞 李文娟 欧阳秋 王泓 候太平 |
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| 作者单位： | 1. 四川大学生命科学学院,成都,610064
2. 四川大学华西第二附属医院,成都,610041 |
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| 基金项目： | 四川省应用基础研究项目(03JY029-083-2);教育部新世纪人才支援计划NCET(04-0868) |
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| 摘 要： | 研究了瑞香狼毒(Stellera chamaejasmeL.)对病原真菌石膏样毛癣菌的抑制作用,并对其活性成分进行了分离纯化.采用无水乙醇浸提瑞香狼毒根粉,并用不同极性溶剂进行依次萃取,结果表明乙酸乙酯萃取物具有较强的抑菌活性,其最低抑菌浓度(MIC)为312.5mg.L-1.然后采用硅胶柱对乙酸乙酯萃取物进行分段柱层析,并结合活性跟踪获得一高活性化合物,其最低抑菌浓度(MIC)为9.8mg.L-1.
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| 关 键 词： | 瑞香狼毒 抑菌活性 石膏样毛癣菌 最低抑菌浓度（MIC） |
| 文章编号： | 0490-6756（2006）03-0697-05 |
| 收稿时间： | 2005-11-13 |
| 修稿时间： | 2005-11-13 |
The Research on Antifungal Constituents from the Root of Stellera chamaejasme L. |
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| GONG Xiao-xia,LI Wen-juan,OUYANG Qiu,WANG Hong,HOU Tai-ping.The Research on Antifungal Constituents from the Root of Stellera chamaejasme L.[J].Journal of Sichuan University (Natural Science Edition),2006,43(3):697-701. |
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| Authors: | GONG Xiao-xia LI Wen-juan OUYANG Qiu WANG Hong HOU Tai-ping |
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| Institution: | College of life Science; Sichuan University,College of life Science; Sichuan University,College of life Science; Sichuan University,West China Second Hospital; Sichuan University,College of life Science; Sichuan University |
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| Abstract: | The antifungal activity of Stellera chamaejasme L.against Trichophyton gypsum was studied,and the antifungal constituents were isolated and purified.The minimum inhibitory concentration(MIC) of the extraction by dipping,systematic extraction from the root of Stellera chamaejasme L.was determined.The results showed that ethyl acetate extract from Stellera chamejasme L.had significant antifungal activity,and the minimum inhibitory concentration(MIC) against Trichophyton gypsum was 312.5mg·L~(-1).A high purity... |
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| Keywords: | Stellera chamaejasme L antifungal activity Trichophyton gypsum minimum inhibitory concentration(MIC) |
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