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| 成都地区人乳头瘤病毒型别分布研究 | |
| 引用本文： | 沈梦婕,丁显平,陈刚毅.成都地区人乳头瘤病毒型别分布研究[J].四川大学学报(自然科学版),2012,49(6):1337-1341. |
| 作者姓名： | 沈梦婕 丁显平 陈刚毅 |
| 作者单位： | 1. 四川大学生命科学学院医学遗传研究所,成都,610064 2. 四川大学生命科学学院医学遗传研究所,成都 610064;重庆市南川生物技术研究院,特色生物资源研究与利用川渝共建重点实验室,重庆 408400 3. 重庆市南川生物技术研究院,特色生物资源研究与利用川渝共建重点实验室,重庆 408400 |
| 基金项目： | 四川省科技厅项目(2011051) |
| 摘 要： | 应用反向膜杂交技术对1668例标本进行型别鉴定和统计分析.在1668例标本中,共检出阳性标本673例,感染率为40.3%;其中单重感染512例,占阳性标本的76.1%,双重感染96例,占阳性标本的14.3%;单重感染中的高危型感染318例,占阳性标本的47.3%,低危型感染194例,占阳性标本的28.8%.结果表明成都地区HPV感染率较高,且以单一基因型感染为主,其中HPV-16感染率最高,其次是HPV-18,低危型HPV感染以HPV-6和HPV-11为主. |
| 关 键 词： | 人乳头瘤病毒 分子流行病学 宫颈癌 |
| 收稿时间： | 2011/5/23 0:00:00 |
The distribution of human papillomaviruses infections in chengdu |
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| SHEN Meng-Jie,DING Xian-Ping and CHEN Gang-Yi.The distribution of human papillomaviruses infections in chengdu[J].Journal of Sichuan University (Natural Science Edition),2012,49(6):1337-1341. | |
| Authors: | SHEN Meng-Jie DING Xian-Ping and CHEN Gang-Yi |
| Institution: | 1.Institute of Medical Genetics,College of Life Science,Sichuan University,Chengdu 610064,China; 2.Biotechnology Academy of Nanchuan,Sichuan-Chongqing Joint Key Laboratory for Bio-resource Research and Vtilization,Chongqing 408400,China) |
| Abstract: | A total of 1668 outpatient women were detected for 23 HPV DNA types with the assay of reverse dot blot.40.3% of those samples were detected positive for HPV infection. Among them, 72.1% were infected by single HPV genotype, 14.3% were infected by two genotypes. In the single infection of HPV, the percentages of high risk HPVs were 47.3%, and the rate of low risk HPVs were 28.8%. It was showed that in the area of Chengdu, HPV infection situation was comparatively severe and most were single infection. Among the high risk HPV infections, HPV 16 prevalence was highest, and among the low risk HPV infections, types 6 and 11 were the most prevalent. |
| Keywords: | human papillomaviruses molecular epidemiology cervical cancer |
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