| 一氧化氮供体的合成及其抗菌性能研究 |
| |
| 引用本文： | 陆秋仙,陈涛,毛雯,吕涛.一氧化氮供体的合成及其抗菌性能研究[J].四川大学学报(自然科学版),2022,59(5):055002. |
| |
| 作者姓名： | 陆秋仙 陈涛 毛雯 吕涛 |
| |
| 作者单位： | 南京诺令生物科技有限公司研发部,南京诺令生物科技有限公司研发部,南京诺令生物科技有限公司研发部,清华大学附属北京清华长庚医院(清华大学临床医学院）妇产科 |
| |
| 基金项目： | 国家自然科学基金（12016A1003） |
| |
| 摘 要： | 一氧化氮供体S-亚硝基-N-乙酰基-DL-青霉胺（SNAP）对微生物生长具有显著的抑制效果. 为了进一步验证SNAP对微生物抗抑作用，本文通过亚硝化反应制备得到SNAP固体，并基于不同SNAP浓度验证其抗菌性能. 结果表明：（1）通过核磁和紫外表征, 我们成功制备得到SNAP；（2）SNAP对大肠杆菌、金黄色葡萄球菌（耐药/非耐药）和淋球菌均表现出明显的抑制作用且具有浓度依赖性，表明SNAP具有广谱抗菌特性. SNAP优良的抗菌特性使其及一氧化氮供体在抗抑菌领域有着广阔的应用前景.
|
| 关 键 词： | SNAP 合成 抗菌 耐药 浓度依赖性 |
| 收稿时间： | 2022/3/9 0:00:00 |
| 修稿时间： | 2022/6/17 0:00:00 |
Study on the synthesis and antibacterial properties of nitric oxide donor |
| |
| Institution: | Department of Research and Development, Novlead Biotechnology Co Ltd,Department of Research and Development, Novlead Biotechnology Co Ltd,Department of Research and Development, Novlead Biotechnology Co Ltd,Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University |
| |
| Abstract: | S-nitroso-N-acetyl-DL-penicillamine (SNAP), a nitric oxide donor, has a significant inhibitory effect on the growth of microorganisms. In order to further verify the antibacterial effect of SNAP on microorganisms, SNAP solids were first prepared through nitrification in this paper, and their antibacterial properties were verified based on different SNAP concentrations. The results showed that: (1) SNAP has been successfully prepared by 1H NMR and UV characterization; (2) SNAP has obvious inhibitory effects on Escherichia coli, Staphylococcus aureus (resistant/non-resistant) and Neisseria gonorrhoeae, and the inhibitory effect is concentration-dependent. The results indicates that SNAP has broad-spectrum antibacterial properties. With excellent antibacterial properties SNAP and nitric oxide donors have broad application prospects in the antibacterial field. |
| |
| Keywords: | SNAP Synthesis Antibacterial Drug-resistance Concentration-dependent |
|
| 点击此处可从《四川大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《四川大学学报(自然科学版)》下载免费的PDF全文 |
|
