丢失毒力质粒的小肠结肠炎耶氏菌实验性感染家兔致病机理研究

本文报告应用致病性血清型丢失毒力质粒Ｙ．ｅ菌株４３９－８０Ｖ－及８２－１４０进行家兔体内感染，通过大体病变、组织病变和细胞病变的观察．研究其致病性及致病机理．结果表明：这两株Ｙ．ｅ．菌感染性与致病性明显弱于对照组──致病性血清型带毒力质粒Ｙ．ｅ菌株，其中．用４３９－８０Ｖ－菌株接种的家兔不发生感染与致病．用ＬＡＢ－Ｂ１８２菌株接种的家兔有排菌，肠粘膜上皮溃疡，急性脾炎病变．但无微脓肿及菌落形成．无组织细胞变性坏死．

Study on Pathogenesis in Rabbits Caused by Experimental Infection of Yersinia Enterocolitica Strains of Lacking Virulence Plasmids

Study on general tissues pathology and cell pathology of infected rabbits with Yersinia enterocolitica strains of pathogenic serotypes and lost virulence plasmids. such as 439-80V--and 82-140. total 6 x 108 inoculations of intravenous injection are reported in this paper. The two rabbits inoculated with 439-80V- have been normal and the other two inoculated with 82-140 have been affected with ulceation of the intestine membrane and acute splenitis but no formation of micro-abscesses and colonies and no degeneration and necroses.