| 地胆草化学成分的研究 |
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| 引用本文： | 黄婷,吴霞,王英,叶文才,李药兰.地胆草化学成分的研究[J].暨南大学学报,2009,30(5). |
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| 作者姓名： | 黄婷 吴霞 王英 叶文才 李药兰 |
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| 作者单位： | 暨南大学,中药及天然药物研究所,广东,广州,510632;暨南大学,中药药效物质基础及创新药物研究广东省重点实验室,广东,广州,510632 |
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| 基金项目： | 国家自然科学基金项目，教育部重点项目，广东省自然科学基金项目 |
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| 摘 要： | 采用硅胶、葡聚糖凝胶Sephadex LH-20和十八烷基硅烷键合硅胶(ODS)等多种色谱技术,对地胆草根部的化学成分进行分离纯化,从地胆草醇提物的乙酸乙酯萃取部位中分离了9个化合物,通过理化性质和波谱数据鉴定化合物1-9的化学结构分别为:大黄素甲醚(1),异香草酸(2),香豆酸(3),对羟基苯甲酸(4),阿魏酸(5),3-甲氧基-4-羟基-桂皮醛(6),豆甾醇-3-O-β-D-葡萄糖(7),豆甾醇(8),吲唑(9).化合物1、2、4、5.6、9为首次从该种植物中分离得到,其中化合物9为一新的天然产物.
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| 关 键 词： | 地胆草 化学成分 酚类化合物 吲唑 |
Chemical Constituents of Elephantopus scaber |
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| HUANG Ting,WU Xia,WANG Ying,YE Wen-cai,LI Yao-lan.Chemical Constituents of Elephantopus scaber[J].Journal of Jinan University(Natural Science & Medicine Edition),2009,30(5). |
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| Authors: | HUANG Ting WU Xia WANG Ying YE Wen-cai LI Yao-lan |
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| Abstract: | The chemical constituents of Elephantopus scaber was separeted and purified by various chromatogramphic technologies, including silica gel, Sephadex LH-20, and ODS columns. Nine com-pounds were obtained from the EtOAc fraction of ethnolic extract of the herb. On the basis of pectroscopic analyses and chemical reactions, the structures of the afforded compounds were identified as physcion (1), isovanillic acid (2), courmaric acid (3), p-hydroxybenzoic acid (4), ferulic acid (5), 3-me-thoxy-4-hydroxyl-cinnamic aldehyde (6), stigmasterol-3-O-β-D-glucoside (7), stigmasterol (8), in-dazole (9). Compounds 1, 2, 4, 5, 6, 9 were isolated from this herb for the first time, and compounds 9 is a new natural product. |
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| Keywords: | Elephantopus scaber chemical constitutes phenolic compounds indazole |
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