| c－Myb基因反义寡核苷酸对K562细胞增殖和生长的影响 |
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| 引用本文： | 李弘,张洹.c－Myb基因反义寡核苷酸对K562细胞增殖和生长的影响[J].暨南大学学报,1996(4). |
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| 作者姓名： | 李弘 张洹 |
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| 作者单位： | 暨南大学医学院发热研究室 |
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| 摘 要： | 用体外培养技术研究了ｃ－Ｍｙｂ基因的ｍＲＮＡ反义寡核苷酸对慢粒Ｋ５６２红白细胞系增殖和生长的影响。结果显示：ｃ－Ｍｙｂ基因反义寡核苷酸在２０～１６０μｇ／ｍｌ时，对细胞的增殖与集落的形成有明显的抑制作用，提示：ｃ－Ｍｙｂ基因在控制白血病细胞增殖与生长中起重要作用
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| 关 键 词： | c－Myb基因 反义寡核苷酸 K562细胞系 细胞培养 |
Effect of Antisense Oligodeoxynucleotide of c-Myb GenemRNA on Prolifcration of K562 Cell Line |
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| Li Hong,Zhang Huan.Effect of Antisense Oligodeoxynucleotide of c-Myb GenemRNA on Prolifcration of K562 Cell Line[J].Journal of Jinan University(Natural Science & Medicine Edition),1996(4). |
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| Authors: | Li Hong Zhang Huan |
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| Institution: | Li Hong 1) Zhang Huan 2) |
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| Abstract: | The effect of antisens oligodeoxynucleotide of c-Myb gene mRNA on prolifcration of K562 cells was studied. Results showed that exposure of K562 cells to antisense oligodeoxynucleotide of c-Myb gene mRNA resulted in inhibition of proliferation and colony formation of K562 cells significantly. It was suggested that c-Myb gene played an important role in the proliferation and growth of leukemic cells. |
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| Keywords: | c-Myb oncogene antisense oligodeoxynucleotide K562 cell line cell culture |
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