| 虎金丸抗大鼠肝纤维化的免疫组化和超微结构观察 |
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| 引用本文： | 黎俏梅,黄兆胜,黄真炎.虎金丸抗大鼠肝纤维化的免疫组化和超微结构观察[J].暨南大学学报,1999,20(6):1. |
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| 作者姓名： | 黎俏梅 黄兆胜 黄真炎 |
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| 作者单位： | ： 黎俏梅 暨南大学医学院中医学系，
广东 广州 510632 |
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| 摘 要： | 目的：观察虎金丸的抗肝纤维化作用及对肝纤维化的免疫组化和超微结构的影响。方法：采用ＣＣｌ４ 后腿皮下注射致大鼠肝纤维化模型。结果：模型组大鼠病理片呈肝纤维化变，ＦＳＣ增生活跃，有较大量的ＩＶ型胶原沉积。超微结构可见大量的胶原纤维生成和成纤维细胞。结论：虎金丸能明显改善上述组织形态学的变化，抑制肝纤维化的形成，改善肝细胞的超微结构。
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| 关 键 词： | 虎金丸 肝纤维化 免疫组化 超微结构 |
| 修稿时间： | 1999-10-19 |
Observations
of immunohistochemical and ultrastructural changes of
the liver of hepatic fibrosis rat treated with Hujin pill |
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| LI Qiao-mei ,HUANG Zhao sheng ,HUANG Zhen-yan ,WANG Zong wei.Observations
of immunohistochemical and ultrastructural changes of
the liver of hepatic fibrosis rat treated with Hujin pill[J].Journal of Jinan University(Natural Science & Medicine Edition),1999,20(6):1. |
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| Authors: | LI Qiao-mei HUANG Zhao sheng HUANG Zhen-yan WANG Zong wei |
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| Institution: | LI Qiao-mei 1,HUANG Zhao sheng 2,HUANG Zhen-yan 2,WANG Zong wei 2 |
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| Abstract: | AimTo observe the effect
of Hujin pills on anti-hepaticfibrosis, immunohistochemical pathological change and
ultrastrcture in rat livers. Methods Carbon tetrachloride (CCl4)
hypodermic injection was used to reproduce the fibrosis liver of rats, and the
immunohistochemical and Ultrastructrural effects of Hujin pills were observed. ResultsThe
pathological sections of the non-treated rat liver appeared fibrosis, and FSC proliferated
actively and a large number IV-collagens deposited in the rat liver. It could also be
observed that a great quantity of collagerous fibers were produced and many FSC turned to
the fibroblast. Conclusion Hujin pills could remarkably lessen the above
steatosis degree, inhibit FSC proliferation and activation ,and almost regain the normal
structure of hepatocytes. |
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| Keywords: | Hujin pill fibrosis liver immunohistochemical pathology ultrastructure |
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