肾移植后伴骨质疏松症患者血清骨代谢指标的变化

应用放射免疫分析法和免疫放射分析法对７例已确诊有骨质疏松症的骨移植患者进行血清骨代谢指标检测。结果表明患者成骨细胞活性指标（血清特异性骨碱怀磷酸酶、骨钙素和Ｉ型前胶原蛋白羧基末端前肽）和破骨细胞功能指标（血清Ｉ型胶原交联羧基末端肽）明显高于正常对照组，患者血清甲状旁腺素和２５羟维生素Ｄ水平正常。提示肾移植后伴骨质疏松症患者的成骨细胞活性和破骨细胞活性明显增高，但无继发性甲状旁腺功能亢进和维生素Ｄ代

Biochemical Markers of Bone Turnover in OsteoporoticBone Matrix after Renal Transplantation

To observe changes of biochemical markers of bone turnover in osteoporotic bone matrix after renal transplantation, osteocalcin, bone alkaline phosphatase(BAP), PICP (carboxyterminal propeptide of type I procollagen), ICTP (carboxyterminal cross-linked telopeptide of type I collagen), parathyroid hormone (PTH) and 25-hydroxy-vitamin D (25 OHD) were measured in 7 patients with osteoporosis followingrenal transplantation (median 6 months, range 1 to 72 months). Using restrictive criteria for defining the presence of osteoporosis when bone mineral density (BMD) measured using dual energy X-ray absorptiometry lay more than 2 SD below the mean of normal subjects of the same age and sex. Mean serum values of bone formation markers such as osteocalcin, BAP, PICP, and bone resorption marker such as ICTP were significantly higher in patients group than those of 38 noormal subjects. Serum PTH and 25OH D levels were normal. These data suggested that this osteoporosis after renal transplantation is associated with a high bone turnover (elevated osteoblastic and osteoclastic activity) without secondary hyperparathyroidism and abnormal vitamin D metabolism.