人正常子宫内膜树突状细胞的周期性变化

目的：研究人正常子宫内膜上树突状细胞(dendritic cell，DC)的分布特点。方法：对10例人正常子宫内膜组织应用HLA-DR单克隆抗体和CD1a蛋白抗体进行免疫组化染色，其中增殖期内膜4例、分泌期内膜3例、绝经期内膜3例，观察其中的阳性细胞。结果：10例正常子宫内膜标本中，5例呈HLA-DR阳性表达(增殖期4例，分泌期1例，绝经期0例)；4例呈CD1a阳性表达(增殖期3例，分泌期1例，绝经期0例)。结论：人正常子宫内膜组织中存在表达主要组织相容性复合体-Ⅱ(MHC-Ⅱ)类分子的DC，各时期的子宫内膜DC检出率不同。

Periodic changes of dendritic cells in the normal endometrium

Aim: To study the distribution of dendritic cells in normal human endometrium. Methods: The monoclonal antibody against HLA-DR and CD1a was used to detect the dendritic cells in normal human endometrium from 10 samples (proliferative phase n=4, secretory phase n=3, postmonopause n=3) by means of immunohistochemical staining. Results: Among 10 cases of normal endometria, 5 cases expressed HLA-DR positive staining (proliferative phase 4 cases, secretory phase 1 case, postmonopause 0 case). 4 cases expressed CD1a positive staining (proliferative phase 3 cases, secretory phase 1 case, postmonopause 0 case). Conclusion: The dendritic cells expressing class II molecules exist in normal human endometrium, and the positive rate of dendritic cells is different between various phases.