| 大豆异黄酮对卵巢切除大鼠糖脂代谢和血清瘦素、抵抗素表达的影响 |
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| 引用本文： | 龚华芳,张亚兴,王晓东,曾耀英.大豆异黄酮对卵巢切除大鼠糖脂代谢和血清瘦素、抵抗素表达的影响[J].暨南大学学报,2011,32(3). |
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| 作者姓名： | 龚华芳 张亚兴 王晓东 曾耀英 |
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| 作者单位： | 暨南大学生命科学技术学院组织移植与免疫实验中心,广东广州,510632 |
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| 基金项目： | “973”国家重点基础研究项目(2006CB504201;2004CB720100) |
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| 摘 要： | 为探讨大豆异黄酮对卵巢切除大鼠糖脂代谢和血清瘦素、抵抗素表达的影响,将12周SD大鼠分成3组,假手术(Sham)组、卵巢切除(OVX)组和大豆异黄酮(OVX+Gen)组,每组7只,卵巢切除术后10 d,OVX组和Sham组大鼠每天腹腔注射生理盐水0.1 ml/只,OVX+Gen组每天注射大豆异黄酮0.2 mg/只,连续注射30 d后处死取血,检测子宫病理改变、血糖血脂和胰岛素水平、血清瘦素和抵抗素含量.结果发现卵巢切除后大鼠总胆固醇、HDL和LDL均增加(P<0.05),但胰岛素、血糖、甘油三酯、血清瘦素和抵抗素水平变化不明显(P>0.05);卵巢切除后补充大豆异黄酮,可促进子宫内膜上皮部分增生,但胰岛素、血糖、总胆固醇、甘油三酯、LDL和HDL、血清瘦素和抵抗素水平均无明显变化(与OVX组相比,P>0.05),结果提示大豆异黄酮对卵巢切除大鼠糖脂代谢参数和血清瘦素、抵抗素水平影响不大.
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| 关 键 词： | 卵巢切除 大豆异黄酮 血糖 血脂 瘦素 抵抗素 |
Effects of genistein on glucose and lipid metabolism and the expression of serum leptin and resistin in ovariectomized SD rats |
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| GONG Hua-fang,ZHANG Ya-xing,WANG xiao-dong,ZENG Yao-ying.Effects of genistein on glucose and lipid metabolism and the expression of serum leptin and resistin in ovariectomized SD rats[J].Journal of Jinan University(Natural Science & Medicine Edition),2011,32(3). |
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| Authors: | GONG Hua-fang ZHANG Ya-xing WANG xiao-dong ZENG Yao-ying |
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| Institution: | GONG Hua-fang,ZHANG Ya-xing,WANG xiao-dong,ZENG Yao-ying(Laboratory of Tissue Transplantation and Immunology,Jinan University,Guangzhou 510632,China) |
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| Abstract: | To delineate the effects of ovariectomy(OVX) and genistein treatment on the levels of glucose,insulin,total cholesterol,LDL,HDL,triglycerides,serum leptin and resistin,female SD rats(12-week old) were divided into three groups,control(Sham),OVX and OVX treated with genistein(OVX+Gen)(n=7,each group).After operation for 10 days,rats were treated with genistein(ip,0.2 mg per day)(OVX+Gen) and vehicle(Sham and OVX rats) for 30 days.The pathological conditions of the uterus,and the levels of glucose,total chole... |
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| Keywords: | ovariectomy genistein glucose lipid leptin resistin |
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