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| 青天葵具抗肿瘤活性石油醚部位的成分研究 | |
| 引用本文： | 卢传礼,王辉,周光雄,王恒山,叶文才,姚新生.青天葵具抗肿瘤活性石油醚部位的成分研究[J].暨南大学学报,2009,30(5). |
| 作者姓名： | 卢传礼 王辉 周光雄 王恒山 叶文才 姚新生 |
| 作者单位： | 1. 暨南大学,中药及天然药物研究所,广东省普通高校重点实验室,中药药效物质基础与创新药物研究重点实验室,广东,广州,510632 2. 暨南大学,医学院微生物教研室,广东,广州,510632 3. 广西师范大学化学化工学院,广西,桂林,541004 |
| 基金项目： | 广西师范大学(省部共建教育部)重点实验室资助课题 |
| 摘 要： | 通过体外抑制肿瘤细胞生长活性筛选确定青天葵95%乙醇(体积分数)提取物及其石油醚萃取部位为抗肿瘤活性部位.综合利用多种色谱手段及重结晶方法从石油醚部位分离得到了8个化合物,并运用理化性质和波谱技术分析确定了化合物结构.其结构分别为:环桉烯醇(cycloeucalenol)(1);豆甾醇(2);谷甾醇(3);熊果酸(4);aurantiamide acetate(5);(20S,22E,24R)-ergosta-7,22-dien-3β,5a,6β-triol(6);6-methoxy-cerevisteml(7);和β-胡萝卜苷(8).其中,化合物3、5、6、7和8均为首次从该植物中分离得到. |
| 关 键 词： | 青天葵 抗肿瘤活性 化学成分 |
Studies on chemical constitutents of petroleum ether extract with anti-tumor activity from Nerviliae fordii |
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| LU Chuan-li,WANG Hui,ZHOU Guang-xiong,WANG Heng-shan,YE Wen-cai,YAO Xin-sheng.Studies on chemical constitutents of petroleum ether extract with anti-tumor activity from Nerviliae fordii[J].Journal of Jinan University(Natural Science & Medicine Edition),2009,30(5). | |
| Authors: | LU Chuan-li WANG Hui ZHOU Guang-xiong WANG Heng-shan YE Wen-cai YAO Xin-sheng |
| Abstract: | The results of the in vitro antitumor activity screenings indicated that 95% ethanol extract and the petroleum ether fraction from the extract showed a significant inhibitory activities on growth of cancer cells. Eight compounds were isolated from this fraction by a combination of various chromatogra-phy methods and re-crystallization. The chemical structures were elucidated on the basis of physico-chem-ical properties and spectral data, and were identified as cycloeucalenol (1) ; stigmaterol (2) ; sitosterol (3) ; ursolic acid (4) ; aurantiamide acetate (5) ; (20S, 22E, 24R)-ergosta-7,22-dien-3β,5α,6β-triol (6) ; 6-methoxy-cerevisterol (7) ; andβ-daucosterol (8). Among these compounds, 3, 5, 6, 7 and 8 are obtained from the plant for the first time. |
| Keywords: | Nerviliaefordii (Hance) Schltr anti-tumor activity chemical constituents |
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