| 大肠癌中MTA1和nm23 - H1蛋白的表达及其意义 |
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| 引用本文： | 杜彬,周序珑.大肠癌中MTA1和nm23 - H1蛋白的表达及其意义[J].暨南大学学报,2005,26(6):751-755. |
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| 作者姓名： | 杜彬 周序珑 |
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| 作者单位： | 暨南大学医学院病理解剖学教研室,广东,广州,510632;暨南大学医学院病理解剖学教研室,广东,广州,510632 |
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| 基金项目： | 暨南大学医学院科研基金（2004001）资助项目 |
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| 摘 要： | 目的：探讨大肠癌中MTA1、nm23-H1蛋白的表达及其意义。方法：用免疫组化留法检测84例大肠癌MTA1、nm23-H1蛋白的表达。结果：84例大肠癌中MTA1、nm23-H1阳性表达率分别为61．9％和51．2％；MTA1高表达与大肠癌组织分化程度、Duke’s分期和淋巴结转移关系密切（P〈0．05）；nm23-H1低表达与大肠癌组织分化程度、Duke’s分期和淋巴结转移关系密切（P〈0．05）；大肠癌中MTA1和nm23-H1蛋白表达呈负相关（P〈0．05）。结论：MTA1和nm23-H1蛋白表达与大肠癌分化程度、淋巴结转移和预后密切相关，可作为判断大肠癌患者转移复发的参考指标。
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| 关 键 词： | 大肠癌 肿瘤转移相关基因 nm23-H1蛋白 |
| 文章编号： | 1000-9965(2005)06-0751-05 |
| 收稿时间： | 05 24 2005 12:00AM |
| 修稿时间： | 2005年5月24日 |
Expression and significance of MTA1, nm23- H1 in human colorectal cancer |
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| DU Bin,ZHOU Xu-long.Expression and significance of MTA1, nm23- H1 in human colorectal cancer[J].Journal of Jinan University(Natural Science & Medicine Edition),2005,26(6):751-755. |
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| Authors: | DU Bin ZHOU Xu-long |
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| Institution: | Department d Pathology, Medical College,Jinan University,Guangzhou, 510632,China |
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| Abstract: | Aim: To detect the expressions of metastasisassociated gene1(MTA1),nm23-H1 protein in human colorectal cancer.Methods: SP immunohistochemical technique was used to detect the expression of MTA1 and nm23-H1 protein among 84 human colorectal cancer samples.Results: The positive rates of MTA1 and nm23-H1 proteins were 61.9% and 51.2% respectively.The over expression of MTA1 and the low expression of nm23-H1 protein were significantly related with Duke's stage,degree of differentiation,and lymph node metastasis(P<0.05).In addition,there is a significant correlation between MTA1 and nm23-H1 in human colorectal cancer(P<0.05).Conclusion: The expression of MTA1 and nm23-H1 is significantly related with degree of differentiation,lymph node metastasis and prognosis in colorectal cancer.MTA1 and nm23-H1 can be useful markers for evaluation of tumor malignancy,judgment of recurrence and metastasis in patients with colorectal cancer. |
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| Keywords: | colorectal cancer MTA1 rim23 - H1 protein |
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