中潜伏期听觉电反应在糖尿病大鼠中的动态变化研究

目的 :探讨中潜伏期听觉电反应 (MLR)在早期诊断糖尿病中枢神经病变 (DCN)中的作用 方法 :应用链脲佐菌素 (STZ)腹腔注射法 ,建立实验性糖尿病 (ED)动物模型 并在成模前后按时间顺序动态观测MLR的变化 结果 :建模后 4周实验性糖尿病 (ED)组出现MLRP0 、Na、Pa、Nb、Pb波峰潜伏期 (PL)延长 (P <0 .0 5) 6周后出现MLR各波PL、Pa-Pb 波峰间潜伏期 (IPL)延长 (P <0 0 1) 8周后MLR各波PL、P0 -Pa、Pa-PbIPL均延长 (P <0 .0 5或P <0 .0 1) ED组血糖与MLR的PL、IPL变化之间无相关 ,ED组病程与MLRNa、Nb、Pb 波PL变化有正相关 结论 :糖尿病早期MLR出现PL和IPL延长 ,该变化与病程进展有相关关系 ,MLR是早期诊断DCN的客观灵敏指标

A study of auditory middle latency response in diabetic rats

Aim:To study the changes of auditory middle latency response(MLR) in diabetic rats and to investigate the role of MLR in the early diagnosis of diabetic central neuropathy (DCN).Methods:Experimental diabetes (ED) rat model was used. Before and after 2,4,6,8 and 10 weeks of ED modeling, MLR was measured. Results:The peak latency (PL) of P0、Na、Pa、Nb、Pb of MLR of ED group prolonged after 4w of ED modeling (P＜0.05). All PL and Pa-Pb interpeak latency (IPL) of MLR prolonged after 6w(P＜0.01). All the PL、P0-Pa、Pa-Pb IPL of MLR prolonged after 8w(P＜0.05, P＜0.01). There was positive correlation between the duration of diabetes and Na、Nb、Pb PL of MLR. Conclusion:The PL and IPL of MLR prolonged in early ED. MLR was sensitive and valuable in the early diagnosis of DCN.