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| 不同穴位处方麦粒灸对失眠大鼠下丘脑单胺类神经递质的影响 | |
| 引用本文： | 宋媛,赵仓焕,任莉.不同穴位处方麦粒灸对失眠大鼠下丘脑单胺类神经递质的影响[J].暨南大学学报,2009,30(2). |
| 作者姓名： | 宋媛 赵仓焕 任莉 |
| 作者单位： | 1. 暨南大学附属第一医院,校门诊部,广东,广州,510630 2. 暨南大学附属第一医院,针灸科,广东,广州,510630 3. 广州市越秀区残疾人康复中心,广东,广州,510100 |
| 基金项目： | 广东省中医药局科研基金 |
| 摘 要： | 目的:观察不同穴位处方麦粒灸对失眠大鼠下丘脑5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NE)、多巴胺(DA)质量分数的变化,探讨麦粒灸治疗失眠症的作用机理.方法:将SD大鼠36只随机分为6组即对照组、模型组、安定组、麦粒灸1组(取百会、神道、心俞穴),麦粒灸2组(取三阴交、神门穴),麦粒灸3组(取申脉、照海穴),模型组以腹腔注射对氯苯丙氨酸(PCPA)建立大鼠失眠模型,安定组给予腹腔注射安定,麦粒灸各组分别按穴位给予麦粒灸治疗,每组连续治疗6 d后检测大鼠下丘脑5-HT、5-HIAA、NE、DA的变化.结果:模型组5-HT和5-HIAA质量分数明显低于对照组(P＜0.01);麦粒灸各组5-HT、5-HIAA明显升高,NE、DA明显降低,与模型组和安定组比较差异有显著性(P＜0.05,P＜0.01);麦粒灸各组之间比较,麦粒灸2组优于麦粒灸1组(P＜0.05),麦粒灸3组与麦粒灸1组、麦粒灸2组比较均无显著性差异(P＞0.05).结论:麦粒灸可能是通过提高失眠大鼠下丘脑5-HT、5-HIAA质量分数,降低NE、DA质量分数而改善睡眠;麦粒灸2组作用优于麦粒灸1组,说明取三阴交、神门穴治疗失眠症疗效更好. |
| 关 键 词： | 失眠症 麦粒灸 穴位处方 单胺类神经递质 动物实验 |
Effect of grain-sized Moxibustion with different acupoint group on monoamine neurotransmitters in the hypothalamus of insomnia rats |
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| SONG Yuan,ZHAO Cang-huan,REN Li.Effect of grain-sized Moxibustion with different acupoint group on monoamine neurotransmitters in the hypothalamus of insomnia rats[J].Journal of Jinan University(Natural Science & Medicine Edition),2009,30(2). | |
| Authors: | SONG Yuan ZHAO Cang-huan REN Li |
| Institution: | 1.Out-patient Department of University;the First Affiliated Hospital;Jinan University;Guangzhou 510630;China;2.Department of Acu-moxibustion;3.Handicapped Healing Center of Yuexiu District;Guangzhou 510100;China |
| Abstract: | Aim:To observe the effects of Moxibustion at different acupoints group on the contents of 5-hydroxytryptamine(5-HT),5-hydroxyindoleacetic acid(5-HIAA),dopamine(DA),and norepinephrine(NE) in the hypothalamus of insomnia rats to investigate the mechanism of Moxibustion treatment of insomnia. Methods: Thirty-six SD rats were randomly divided into six groups: controlled group,model group,diazepam group,grain-sized Moxibustion group I(Baihui(DU20),Shendao(DU11),Xinshu(BL15)),grain-sized Moxibustion group II(Sany... |
| Keywords: | insomnia grain-sized Moxibustion acupoint group monoamine neurotransmitters animal experiment |
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