| 用离子液体四氟硼酸正丁基吡啶盐作催化剂和反应介质合成3,4 -二氢嘧啶-2-酮 |
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| 引用本文： | 周美云,李毅群.用离子液体四氟硼酸正丁基吡啶盐作催化剂和反应介质合成3,4 -二氢嘧啶-2-酮[J].暨南大学学报,2006,27(3):435-438. |
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| 作者姓名： | 周美云 李毅群 |
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| 作者单位： | 暨南大学化学系,广东,广州,510632 |
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| 基金项目： | 中国科学院资助项目;广东省自然科学基金;教育部留学回国人员科研启动基金 |
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| 摘 要： | 采用离子液体四氟硼酸正丁基吡啶盐(bpy]BF4)作催化剂和反应介质,芳香醛、乙酰乙酸乙酯、尿素进行三组分B iginelli缩合,制备了3,4-二氢嘧啶-2-酮衍生物.结果表明,反应时间短、操作简便、产率60%~70%、不需使用有机溶剂,离子液体可重复使用,对环境友好.
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| 关 键 词： | 离子液体 Biginelli缩合 3 4-二氢嘧啶-2-酮 |
| 文章编号： | 1000-9965(2006)03-0435-04 |
| 修稿时间： | 2005年9月29日 |
Synthesis of 3,4 - dihydropyrimidin - 2 ( 1 H) - ones using ionic liquid n -butyl pyridinium tetrafluoroborate as a catalyst and medium |
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| ZHOU Mei-yun,LI Yi-qun.Synthesis of 3,4 - dihydropyrimidin - 2 ( 1 H) - ones using ionic liquid n -butyl pyridinium tetrafluoroborate as a catalyst and medium[J].Journal of Jinan University(Natural Science & Medicine Edition),2006,27(3):435-438. |
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| Authors: | ZHOU Mei-yun LI Yi-qun |
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| Abstract: | Dihydropyrimidiones and their derivatives were synthesized by the Biginelli three component condensation of aromatic aldehydes,ethyl acetoacetate ester and urea(using) room temperature ionic liquid n-butyl pyridinium tetrafluoroborate BF_4 as a(catalyst) and medium.The results showed the protocol has the advantages such as short reaction time,simple procedures,moderate yields,the ionic liquid reusability and benign to environmental without using organic solvent. |
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| Keywords: | ionic liquid Biginelli condensation 3 4-dihydropyrimidine-2(1H)-ones |
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