| 纤维素三苯甲酯手性固定相的制备及对映体的拆分 |
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| 引用本文： | 张鹏,胡坪,陆蕾,苏克曼.纤维素三苯甲酯手性固定相的制备及对映体的拆分[J].华东理工大学学报(自然科学版),2002,28(1):79-82. |
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| 作者姓名： | 张鹏 胡坪 陆蕾 苏克曼 |
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| 作者单位： | 华东理工大学化系学,上海,200237 |
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| 摘 要： | 用微晶纤维素和苯甲酰氯的超声反应合成了纤维素三苯甲酯 ( CTB) ,并将其涂敷于硅胶上 ,用作液相色谱手性固定相。在正相条件下 ,用此手性固定相对一系列外消旋缩水甘油芳香基醚类化合物进行了拆分 ,并对拆分机理进行了探讨。考察了流动相中添加不同的醇对缩水甘油间甲基苯基醚对映体拆分的影响
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| 关 键 词： | 手性固定相 纤维素三苯甲酯 对映体分离 缩水甘油芳香基醚 |
| 文章编号： | 1006-3080(2002)01-0079-04 |
| 修稿时间： | 2001年3月8日 |
Preparation of Cellulose Tribenzoate as Chiral Stationary Phase in HPLC and Separation of Enantiomers on It |
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| ZHANG Peng,HU Ping,LU Lei,SU Ke man.Preparation of Cellulose Tribenzoate as Chiral Stationary Phase in HPLC and Separation of Enantiomers on It[J].Journal of East China University of Science and Technology,2002,28(1):79-82. |
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| Authors: | ZHANG Peng HU Ping LU Lei SU Ke man |
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| Institution: | ZHANG Peng,HU Ping,LU Lei,SU Ke man * |
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| Abstract: | Cellulose tribenzoate chiral stationary phase(CTB CSP) was prepared by a modified procedure, in which CTB was synthesized by the ultrasonic reaction of benzoyl chloride with microcrystalline cellulose and then was coated on the silica gel. Enantiomers of a series of glycidyl aromatic ethers were separated by CTB CSP in normal chromatographic conditions. The chiral recognition mechanism was discussed for the separation of these chiral glycidyl aromatic ethers. The effects of different alcohols in mobile phase on the chiral separation of glycidyl m tolyl ether enantiomers were also investigated. |
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| Keywords: | chiral stationary phase cellulose tribenzoate enantiomer separation glycidyl aromatic ether |
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