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| 无溶剂超临界喷射成型技术制备溶菌酶/PLA纤维制剂及其体外缓释性能 | |
| 引用本文： | 吕蔚,颜德岳,何扣宝.无溶剂超临界喷射成型技术制备溶菌酶/PLA纤维制剂及其体外缓释性能[J].华东理工大学学报(自然科学版),2006,32(10):1160-1163. |
| 作者姓名： | 吕蔚 颜德岳 何扣宝 |
| 作者单位： | 1. 上海交通大学化学化工学院,上海,200240;上海华谊(集团)公司,上海,200025 2. 上海交通大学化学化工学院,上海,200240 3. 上海华谊(集团)公司,上海,200025 |
| 摘 要： | 利用无溶剂超临界二氧化碳喷射成形技术,制备可降解高分子溶菌酶缓释纤维,并对其体外溶菌酶释放性能进行了研究。通过条件试验确定了最适合的成形工艺参数;选择有代表性的聚乳酸(PLA)作为主体缓释材料,溶菌酶作为溶菌酶实验对象,建立了上述溶菌酶制剂体系的体外缓释模型和分析方法;结合缓释材料的降解情况对溶菌酶缓释的机理进行了研究。 |
| 关 键 词： | 超临界CO2 无溶剂 PLA纤维 溶菌酶缓释 喷射成型 |
| 文章编号： | 1006-3080（2006）10-1160-04 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005年11月15 |
Lysozyme/PLA Fibers Prepared by Supercritical Spray Process without Solvent and Their Drug Delivery Performance |
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| L Wei,YAN De-yue,HE Kou-bao.Lysozyme/PLA Fibers Prepared by Supercritical Spray Process without Solvent and Their Drug Delivery Performance[J].Journal of East China University of Science and Technology,2006,32(10):1160-1163. | |
| Authors: | L Wei YAN De-yue HE Kou-bao |
| Institution: | L(U) Wei,YAN De-yue,HE Kou-bao |
| Abstract: | The supercritical spray process is a useful technique for producing degradable polymer fibers for controlled drug delivery applications.PLA was used as the processing polymer for controlled(delivery) of lysozyme.Lysozyme polymer fibers were produced from super critical spray process under the(optimized) parameters of the instrument.The mode and analysis method of drug delivery out of the body was established.Furthermore,the drug delivery by combination with the degradation of PLA was studied. |
| Keywords: | supercritical CO_2 without organic solvents PLA fibers drug delivery spray process |
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