| 黄芩苷固体分散体的研制 |
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| 引用本文： | 岳红坤,周冉,王景翔,马珊珊.黄芩苷固体分散体的研制[J].井冈山大学学报（自然科学版）,2013(2):89-93. |
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| 作者姓名： | 岳红坤 周冉 王景翔 马珊珊 |
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| 作者单位： | 石家庄学院化工学院,河北石家庄050035 |
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| 摘 要： | 目的研制黄芩苷固体分散体，并对其进行考察。方法以PEG6000为载体，用溶剂法、熔融法、溶剂．熔融法、研磨法制备黄芩苷固体分散体，并通过紫外、红外、溶解度、溶出度的考察比较不同药物与载体的比例对固体分散体的影响。结果溶剂法即共沉淀法，药物与PEG6000的比例为1：8时的固体分散体最优。结论制备方法和药物与载体的比例都会影响黄芩苷-PEG6000固体分散体的质量。
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| 关 键 词： | 黄芩苷 固体分散体 溶出度 溶剂法 |
RESEARCH ON BAICALIN SOLID DISPERSION |
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| YUE Hong-kun,ZHOU Ran,WANG Jing-xiang,MA Shan-shan.RESEARCH ON BAICALIN SOLID DISPERSION[J].Journal of Jinggangshan University(Natural Sciences Edition),2013(2):89-93. |
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| Authors: | YUE Hong-kun ZHOU Ran WANG Jing-xiang MA Shan-shan |
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| Institution: | (College of Cheminal Technology, Shijiazhuang University, Shijiazhuang, Hebei 050035, China) |
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| Abstract: | Objective ： To prepare and investigate baicalin solid dispersion. Methods： Using PEG6000 as cartier, baicalin solid dispersion was prepared by solvent, melting, solvent-melting, grinding methods. The influence on solid dispersion of different proportion was studied by UV, IR, solubility and dissolution rate. Results： The solid dispersions of solvent method and the ratio of the drug and PEG6000 1：8 is the best. Conclusion： The quality of solid dispersion was affected by the preparation method and the ratio. |
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| Keywords: | baicalin solid dispersion dissolution rate solvent method |
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