陆英不同部位水提液抗炎镇痛作用的比较研究

目的比较陆英不同部位水提液的抗炎镇痛作用。方法采用二甲苯致小鼠耳肿胀炎症模型,研究陆英不同部位水提液灌胃给药对急性炎症的作用。采用热板法和醋酸扭体法致痛,研究陆英不同部位水提液灌胃给药的镇痛作用。结果与模型组相比,陆英根与茎叶水提液高、低剂量(10.0、5.0 g生药/kg)组显著抑制二甲苯所致小鼠耳肿胀(P0.01)。陆英根与茎叶水提液高、低剂量(10.0、5.0 g生药/kg)组给药后明显延长热板所致小鼠的痛阈值,与模型组和自身给药前比较差异极显著(P0.01);陆英根与茎叶水提液高、低剂量(10.0、5.0 g生药/kg)组明显减少醋酸所致小鼠扭体反应次数,与模型组比较差异极显著(P0.01)。陆英根水提液高、低剂量组给药后与相同剂量的茎叶水提液相比,差异显著(P0.05、P0.01)。结论陆英根与茎叶水提液灌胃给药均具有抗炎、镇痛作用,且根水提液抗炎镇痛作用强于茎叶水提液。

COMPARISON ON THE ANTI-INFLAMMATORY AND ANALGESIC EFFECTS OF THE WATER EXTRACTS FROM DIFFERENT PARTS OF SAMBUCUS CHINENSIS

Objective: To compare the anti-inflammatory and analgesic effects of the water extracts from different parts of Sambucus chinensis. Methods: The anti-inflammatory animal model were used in researching the effects of the water extracts from different parts of S. chinensis on acute inflammation. The acute model were xylene-induced ear swelling. Meanwhile, the analgesic effects of that extracts were observed by hot plate and acetic acid writhing test. Results: Compared with the model group, high and low doses (10.0, 5.0 g/kg) of water extracts of S. chinensis root and stem leaf could significantly inhibit ear swelling in mice (P < 0.01). Moreover, the pain threshold with hot plate method was significantly prolonged (P < 0.01) compared with the model group and the data before the drugs administration of high and low doses (10.0, 5.0 g/kg) of water extracts of S. chinensis root and tem leaf. And the writhing number was reduced (P < 0.01) when contrasted to the model group after extracts administration. However, there were substantial variations in the root water extract group and the same dose of stem leaf water extract in high and low concentrations (P < 0.05, P < 0.01). Conclusion: S. chinensis root and tem leaf water extracts possesses the anti-inflammatory and analgesic effects, and root water extracts have better effects.