铁苋菜提取物镇痛作用研究

目的 探讨铁苋菜提取物的抗炎镇痛作用。方法 应用二甲苯刺激引起的小鼠耳廓肿胀炎症模型，探讨铁苋菜提取物经胃注药对小鼠耳廓肿胀炎症的减轻作用；应用热板刺激和将醋酸注入腹腔刺激腹膜引起小鼠扭体反应的疼痛模型，探讨铁苋菜提取物经胃注药对疼痛的减轻作用。结果 与生理盐水组相比较，铁苋菜水提物和醇提物低、高剂量（3.0、6.0 g生药/kg）组对二甲苯刺激所引起的小鼠耳廓肿胀炎症抑制作用显著（P < 0.01）。铁苋菜水提物和醇提物低、高剂量（3.0、6.0 g生药/kg）组给药后对热板刺激所引起的小鼠痛阈值延长显著，与生理盐水组和它本身给药前痛阈值相比较具有极明显的差异（P < 0.01）；铁苋菜水提物和醇提物低、高剂量（3.0、6.0 g生药/kg）组对醋酸刺激所引起的小鼠扭体反应的次数减少显著，与生理盐水组相比较具有极明显的差异（P < 0.01）。铁苋菜水提物低、高剂量组给药后与同等剂量的醇提物相比较，具有明显差异（P < 0.05、P < 0.01）。结论 铁苋菜提取物经胃注药均具有一定抗炎、镇痛作用，且水提物抗炎镇痛作用较醇提物强。

ANTI-INFLAMMATORY AND ANALGESIC EFFECT OF ACALYPHA AUSTRALIS EXTRACT

Objective: To investigate the relieving effect against inflammation and pain of Acalypha australis extract in mice. Methods: The models of auricle swelling in mice caused by xylene and the models of pain in mice caused by hot plate stimulation and acetic acid were used to investigate the anti-inflammatory and analgesic effect of low, high doses of A. australis extract, respectively. Results: Compared with the normal saline group, the water extract and alcohol extract could evidently reduce auricle swelling in mice (P < 0.01). Compared with the saline group and the pre administration, the pain threshold with hot plate stimulation treated with the water extract and alcohol extract was significantly prolonged (P < 0.01). And the writhing times after extract administration was significantly reduced (P < 0.01) than those in the normal saline group. However, there were significant differences between the water extract groups and the alcohol extract groups at the same concentrations (P < 0.05, P < 0.01). Conclusion: A. australis extract had the anti-inflammatory and analgesic effect, water extract had higher effect than alcohol extract.