| 增塑剂邻苯二甲酸二乙基己酯对小鼠学习和记忆能力的影响 |
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| 引用本文： | 唐佳琦,张平,袁烨,郭靖,廖晓梅,杨旭.增塑剂邻苯二甲酸二乙基己酯对小鼠学习和记忆能力的影响[J].玉林师范学院学报,2011,32(2):7-11. |
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| 作者姓名： | 唐佳琦 张平 袁烨 郭靖 廖晓梅 杨旭 |
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| 作者单位： | 1. 华中师范大学生命科学学院遗传调控和整合生物学湖北省重点实验室,湖北武汉,430079
2. 华中师范大学国有资产管理办公室,湖北武汉,430079 |
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| 基金项目： | 国家自然科学基金面上项目 |
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| 摘 要： | 目的研究邻苯二甲酸二乙基已酯（di-（2-ethylhexyl）phthalate,DEHP）对于小鼠学习与记忆能力影响.方法48只雄性昆明小鼠随机平均分成4组,分别暴露在0、5、50、500mg/kgDEHP进行经口灌胃染毒,期间进行Morris水迷宫测试检测器学习与记忆能力,染毒结束后取出脑组织,检测ROS水平及MDA含量.结果Morris水迷宫实验结果显示50、500mg/kg DEHP对小鼠学习能力产生影响,50mg/kg浓度DEHP染毒组小鼠记忆能力与对照组相比显著下降（P〈0.05）;随着DEHP染毒浓度的升高小鼠脑组织中的ROS水平和MDA含量逐渐上升,且在50mg/kg和500mg/kg浓度时与对照组相比具有显著性差异（P〈0.05）.结论DEHP能够影响小鼠学习与记忆能力,并对其脑组织产生氧化损伤.
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| 关 键 词： | 邻苯二甲酸二乙基己酯 Morris水迷宫 学习 记忆 活性氧 丙二醛 氧化损伤 |
Effect of DEHP on the Learning and Memory Ability of Kunming Mice |
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| TANG Jia-qi,ZHANG Ping,YUAN Ye,GUO Jing,LIAO Xiao-mei,YANG Xu.Effect of DEHP on the Learning and Memory Ability of Kunming Mice[J].Journal of Yulin Teachers College,2011,32(2):7-11. |
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| Authors: | TANG Jia-qi ZHANG Ping YUAN Ye GUO Jing LIAO Xiao-mei YANG Xu |
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| Institution: | TANG Jia-qi1,ZHANG Ping2,YUAN Ye1,GUO Jing1,LIAO Xiao-mei1,YANG Xu1(1.Hubei Key Laboratory of GeneticRegulation and Integrative Biology,College of Life Science,Central China Normal University,Wuhan,Hubei 430079,2.Office of State-owned Assets Management,Hubei 430079) |
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| Abstract: | Objective: To study the effects of DEHP on learning and memory of the KM mice.Methods: Forty-eight male KM mice were randomly assigned into 4 groups(n=12),exposed to different concentrations of DEHP(0,5,50 and 500 mg/kg) for ten days.During the exposing period,the Morris water maze was used to test the learning abilities and memory.Then the reactive oxygen species(ROS) level and malondialdehyde(MDA) content of brains were measured.Results: The results showed that along with the increase of DEHP concentratio... |
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| Keywords: | Di-(2-ethylhexyl)phthalate(DEHP) Morris water maze Learning abilities Memory Reactive oxygen species(ROS) Malondialdehyde(MDA) Oxidative damage |
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