瑶药五指毛桃对受辐射小鼠肺组织病理形态学的影响

目的：探讨瑶药五指毛桃对受辐射小鼠肺组织病理形态学的影响.方法：6Gy 60Coγ射线单次全肺照射建立肺损伤模型,30只SPF级雄性小鼠随机分阴性对照组、单纯照射组及五指毛桃水提液低、中、高剂量给药组,灌胃给药连续15天.对各组小鼠的肺外观、肺组织进行观察和比较.结果：照射给药组小鼠较单纯照射组肺表面光滑、弹性好、充血水肿表现轻,组织炎性渗出少.结论：瑶药五指毛桃能够改善小鼠肺组织的炎性渗出,减少肺细胞损伤,对放射性肺损伤具有一定的防治作用.

Histopathomorphologic Effect of Yao Medicine Ficus simplicissima Lour on Mice's Radiation-induced Lung Injury

Obiective：To investigate the histopathomorphologic effect of Yao medicine Ficus simplicissima Lour on mice’s radiation-induced lung injury.Methods： To establish injury model,mice were exposed to 6Gy 60Coγ-ray for one time.Thirty SPF mice were divided into five groups：Negative control group,model group,high Ficus simplicissima Lour extract dosage group,middle dosage group,and low dosage groups.The surfaces and tissues of mice’s lung were observed and compared after controlling for 15 days.Results： Compared to the model group,the lung’s surfaces of mice in Ficus simplicissima Lour extract groups were smoother and more elastic,less congestive edema and inflammatory exudation.Conclusion： Ficus simplicissima Lour extract decreases the inflammatory exudation and cells’ injury of lung tissues,and provides prevention and treatment on radiation-induced injury.