| 碘催化下苯硫酚和环己酮及其衍生物合成2-芳硫基苯酚类化合物的研究 |
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| 引用本文： | 廖云峰,姜鹏程,陈善平,齐红蕊,邓国军.碘催化下苯硫酚和环己酮及其衍生物合成2-芳硫基苯酚类化合物的研究[J].中国科技论文在线,2013(12):1266-1270. |
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| 作者姓名： | 廖云峰 姜鹏程 陈善平 齐红蕊 邓国军 |
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| 作者单位： | [1]湘潭大学化学学院,湖南湘潭411105 [2]湖南工程学院化学化工-学院,湖南湘潭411104 |
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| 基金项目： | 高等学校博士学科点专项科研基金资助项目（20124301110005）;国家自然科学基金资助项目（21172185,21372187） |
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| 摘 要： | 2-芳硫基苯酚及其衍生物可以用作GlyT-1抑制剂。笔者发展了一种2-芳基硫醚苯酚的合成新方法，反应过程中以氧气作为氢的接受剂，以环己酮作为苯酚基来源，不需要任何金属参与，使用催化量的碘提高了反应产率，环己酮作为苯酚基来源。
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| 关 键 词： | 有机化学 2-芳硫基苯酚 环己酮 碘催化 无金属 |
2-（Aryl）thiophenoi formation from thiol and cyclohexanones by iodine-catalyzed transformation |
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| Institution: | Liao Yunfeng, J iang Pengcheng ,Chen Shanping , Qi Hongrui1 , Deng Guoj un College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China ; School of Chemistry Chemical Engineering, Hunan Institute of Engineering, Xiangtan , Hunan 411104, China |
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| Abstract: | Aryl thioethers are important organosulfur compounds that widely exist in natural products, functional materials and pharmaceuticals. 2-Phenylthiophenol and its derivatives can be used as glycine transporter-1 （GlyT-1） inhibitors. In this paper, we have developed a novel iodine-promoted approach for the synthesis of 2-（aryl）thiophenols using cyclohexanones as phenol source under metal-free conditions. Catalytic amount of iodine was used as catalyst and molecule oxygen was used as hydrogen ac- ceptor in this transformation. |
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| Keywords: | organic chemistry 2-arylthiophenols cyclohexanones iodine-catalyzed ~ metal-free |
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