鱼藤根中鱼藤素、脱氢鱼藤素的稳定性研究

比较鱼藤素、脱氢鱼藤素在不同溶剂中的溶解性;采用高效液相色谱,分析鱼藤素、脱氢鱼藤素的光稳定性、热稳定性、微波稳定性和耐酸碱性。结果表明,鱼藤素、脱氢鱼藤素在甲醇、乙醇、乙二醇、乙腈、丙酮、氯仿、四氯化碳、乙酸乙酯中具有良好的溶解性;光照条件下,鱼藤素发生不同程度的分解,脱氢鱼藤素则较为稳定;80℃水域加热、微波均未对鱼藤素、脱氢鱼藤产生影响;酸性条件下,鱼藤素、脱氢鱼藤素相对较稳定,碱性条件下,鱼藤素结构发生改变。

Stability of deguelin and dehydrodeguelin in the rootage of derris trifoliata lour

Solubilities of deguelin and dehydrodeguelin in variety of solvents are compared and the effect of light, heat, microwave and pH on deguelin and dehydrodeguelin is studied by High Performance Liquid Chromatography （HPLC）. The results show that both deguelin and dehydrodeguelin are well dissolved in methanol, ethanol, glycol, acetonitrile, acetone, chloroform, carbon tetrachloride and ethyl acetate. And deguelin is decompounded by light while dehydrodeguelin is relatively stable. Neither deguelin nor dehydrodeguelin is changed by heat and microwave. As pH is lower than 7, both deguelin and dehydrodeguelin are stable. However, the structure of deguelin is changed distinctly when pH is higher than 7.