含萘环结构的手性Salen-Mn(Ⅲ)配合物与DNA的相互作用 |
| |
引用本文: | 彭斌,;巢晖,;计亮年.含萘环结构的手性Salen-Mn(Ⅲ)配合物与DNA的相互作用[J].中国科技论文在线,2008(9):698-702. |
| |
作者姓名: | 彭斌 ;巢晖 ;计亮年 |
| |
作者单位: | [1]湖南科技大学化学化工学院,湖南湘潭411201; [2]中山大学化学化工学院,广州510275 |
| |
基金项目: | 国家自然科学基金(20771105); 湖南科技大学科研启动基金 |
| |
摘 要: | 合成含萘环结构的手性Salen-Mn(III)配合物,Mn(III)L]+Cl(L=N,N’-bis-(2-hydroxynaphthalene-1-carbaldehyde)-(1R,2R)-(-)-diaminocyclohexane(R)和N,N’-bis-(2-hydroxynaphthalene-1-carbaldehyde)-(1S,2S)-(+)-diamino-cyclohexane(S)),运用紫外光谱滴定和粘度实验,研究配合物与DNA的插入作用。并通过凝胶电泳观察配合物对pBR322DNA的断裂情况,结果表明配合物以插入模式与DNA结合,呈现出手性差异;在H2O2存在下,配合物能够使pBR322DNA断裂。
|
关 键 词: | 无机化学 DNA作用 实验研究 锰配合物 Salen配体 |
Interaction of DNA with chiral [Salen-Mn~(Ⅲ)]~+ containing naphthyl |
| |
Institution: | PENG Bin,CHAO Hui,JI Liangnian (1. School School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201; 2. School School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou 510275) |
| |
Abstract: | Two chiral bridge-substituted manganese(III) complexes Mn(III)L]+Cl (L=N,N’-bis-(2 -hydroxynaphthalene-1-carbaldehyde)-(1R,2R)-(-)-diaminocyclohexane (R) and N,N’-bis-(2-hydroxynaphthalene-1-carbaldehyde)-(1S,2S)-(+)-diaminocyclohexane (S)) are synthesized. The interaction of these complexes with calf thymus DNA is investigated by spectroscopic and viscosity measurements. Results of spectroscopic and viscosity measurements suggest that the two complexes bind to DNA via an intercalative mode and display enantioselectivity. These Mn(III) complexes are found to promote the cleavage of plasmid DNA pBR322 in the presence of H2O2. |
| |
Keywords: | inorganic chemistry DNA binding expriment research Mn complex Salen ligand |
本文献已被 维普 等数据库收录! |
|