| Statistical analysis on protein-protein interface in crystals： Specific and non-specific interfaces are differentially distributed |
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| 作者姓名： | FENGDan ZENGZonghao |
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| 作者单位： | InstituteofBiophysics,ChineseAcademyofSciences,Beijing100101,China |
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| 摘 要： | The distribution of contact areas, or fractions of contacting, of protein-protein interfaces in crystals of pure polypeptides contains two components: a major exponential distribution and a minor flatter distribution. Suppose the two components belong to specific and non-specific contacts,respectively, then the probability of a contact with a givena rea, or fraction of contacting, can be estimated. By dividing the whole database into two sub-databases, one of them is known to contain more specific contacts than the other, this hypothesis is confirmed and it is also proved that the fraction of contacting is more effective than the contact area on discriminating specific and non-specific contacts in protein crystals.
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| 关 键 词： | 缩多氨酸 指数分布 蛋白质结晶 晶体结构 |
| 收稿时间： | 2003-06-04 |
| 修稿时间： | 2003-12-11 |
Statistical analysis on protein-protein interface in crystals: Specific and non-specific interfaces are differentially distributed |
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| FENGDan ZENGZonghao.Statistical analysis on protein-protein interface in crystals: Specific and non-specific interfaces are differentially distributed[J].Chinese Science Bulletin,2004,49(3):273-276. |
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| Authors: | Dan?Feng Email author" target="_blank">Zonghao?ZengEmail author |
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| Institution: | FENG Dan & ZENG Zonghao Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | The distribution of contact areas, or fractions of contacting, of protein-protein interfaces in crystals of pure polypeptides contains two components: a major exponential distribution and a minor flatter distribution. Suppose the two components belong to specific and non-specific contacts, respectively, then the probability of a contact with a given area, or fraction of contacting, can be estimated. By dividing; the whole database into two sub-databases, one of them is known to contain more specific contacts than the other, this hypothesis is confirmed and it is also proved that the fraction of contacting is more effective than the contact area on discriminating specific and non-specific contacts in protein crystals. |
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| Keywords: | crystal structure protein-protein interface statistical analysis specific interface protein oligomer |
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