| Effects of lithium chloride on outward potassium currents in acutely isolated hippocampal CA1 pyramidal neurons |
| |
| 作者姓名： | ZHANG Chaofeng DU Huizhi YANG Pin |
| |
| 作者单位： | Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China |
| |
| 基金项目： | Acknowledgements This work was supported by the National Natural Science Foundation of China （Grant No. 30470408）. |
| |
| 摘 要： | Lithium is best known for its therapeutic efficacy in the treatment of manic-depressive illness. Its clinical profile includes the antimanic and antidepressant ac- tions as well as prophylaxis of both mania and depres- sion. Despite its efficacy, the mole…
|
| 关 键 词： | 氯化锂 CA1神经原 钾电流 patch-clamp技术 海马 |
| 收稿时间： | 2006-02-23 |
| 修稿时间： | 2006-02-232006-05-31 |
Effects of lithium chloride on outward potassium currents in acutely isolated hippocampal CA1 pyramidal neurons |
| |
| ZHANG Chaofeng DU Huizhi YANG Pin.Effects of lithium chloride on outward potassium currents in acutely isolated hippocampal CA1 pyramidal neurons[J].Chinese Science Bulletin,2006,51(16):1961-1966. |
| |
| Authors: | Chaofeng Zhang Huizhi Du Pin Yang |
| |
| Institution: | (1) Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan, 030006, China |
| |
| Abstract: | Although lithium possesses neuroprotective functions, the molecular mechanism underlying its actions has not been fully elucidated.
In the present paper, the effects of lithium chloride on voltage-dependent potassium currents in the CA1 pyramidal neurons
acutely isolated from rat hippocampus were studied using the whole-cell patch-clamp technique. Depolarizing test pulses activated
two components of outward potassium currents: a rapidly activating and inactivating component, I
A and a delayed component, I
K. Results showed that lithium chloride increased the amplitude of I
A in a concentration-dependent manner. Half enhancement concentration (EC
50) was 22.80±5.45 μmol·L−1. Lithium chloride of 25 μmol·L−1 shifted the steady-state activation curve and inactivation curve of I
A to more negative potentials, but mainly affected the activation kinetics. The amplitude and the activation processes of I
K were not affected by lithium chloride. The effects of lithium chloride on potassium channel appear to possess neuroprotective
properties by Ca2+-lowing effects modulate neuronal excitability by activating I
A in rat hippocampal neurons. |
| |
| Keywords: | lithium chloride CA1 neuron potassium current patch-clamp technique |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ |
| 点击此处可从《中国科学通报(英文版)》浏览原始摘要信息 |
| 点击此处可从《中国科学通报(英文版)》下载免费的PDF全文 |
