Effects of isolation after sexual experience on anxiety-like,depressive-like behaviors and affective states in male rats |
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Authors: | Fei Wen Lin Xu |
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Institution: | (1) Laboratory of Learning and Memory and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, China;(2) Graduate University of the Chinese Academy of Sciences, Beijing, 100049, China;(3) Mental Health Institute, the 2nd Hospital of Central South University, Changsha, 410011, China; |
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Abstract: | Studies on social isolation have provided evidence for an enhanced anxiety-like phenotype, depressive-like symptoms and higher
levels of 22-kHz ultrasonic vocalizations (USVs); whereas sexual experience could induce significant changes in affective
states, decrease anxiety- and depressive-like responses. However, the behavioral and emotional alterations in male rats exposed
to isolation after sexual experience remain poorly understood. Therefore, the present study examined anxiety- and depressive-like
parameters, as well as USV emissions in male rats isolated for 1, 2, or 7 d following 1-week sexual (male-female paired housing)
or social (male-male paired housing) interaction. Isolation for 1 d resulted in increased depressive-like symptoms, and 2-d
isolation induced elevated anxiety-like behavior in sexually inexperienced rats, while rats with sexual experience exhibited
comparable levels of emotionality at each isolation time. Moreover, isolated rats without sexual experience emitted less 22-
and 50-kHz USVs, but sexually experienced rats exhibited similar affective states compared with control ones. These results
suggested that prior sexual experience could have a modulatory effect on experimental rat emotional responses to isolation. |
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