| Two neuropeptides from synganglia of the hard tick, Ixodes sinensis （Acari： Ixodidae） |
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| 作者姓名： | LI Jianxu LIU Tongguang YANG Hailong XU Xueqing LIU Zhigang LAI Ren |
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| 作者单位： | [1]Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China [2]Graduate School of the Chinese Academy of Sciences, Beijing 100009, China [3]Shengyang Orthopaedic Hospital, Shengyang 110044, China [4]College of Biological Sciences, Shenzhen University, Shenzhen518060, China |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China （Grant No. 30570360）, Natural Science Foundation of Yunnan Province （Grant No. 2005C0054M） and Natural Science Foundation of Jiangsu Province （Grant No. BK2005422） |
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| 摘 要： | Two neuropeptides were isolated from synganglia (central nervous system) of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antino-ciceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host's defensive reaction.
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| 关 键 词： | 神经肽 弛缓效应 第一序列 生物化学 |
| 收稿时间： | 2005-09-09 |
| 修稿时间： | 2005-09-092006-09-27 |
Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae) |
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| LI Jianxu LIU Tongguang YANG Hailong XU Xueqing LIU Zhigang LAI Ren.Two neuropeptides from synganglia of the hard tick, Ixodes sinensis (Acari: Ixodidae)[J].Chinese Science Bulletin,2006,51(22):2743-2747. |
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| Authors: | Jianxu Li Tongguang Liu Hailong Yang Xueqing Xu Zhigang Liu Ren Lai |
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| Institution: | (1) Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China;(2) Graduate School of the Chinese Academy of Sciences, Beijing, 100009, China;(3) Shengyang Orthopaedic Hospital, Shengyang, 110044, China;(4) College of Biological Sciences, Shenzhen University, Shenzhen, 518060, China |
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| Abstract: | Two neuropeptides were isolated from synganglia (central nervous system) of the hard tick, Ixodes sinensis. Their primary sequences were established as Leu-Val-Val-Tyr-Pro-Trp-Thr-Lys and Trp-Glu-Lys-Leu-Gly-Ser-Met-Glu-Thr-Leu. By hot plate bioassay, neuropeptide a displayed strong antino-ciceptive effect in mice by a dose-dependent behavior, while neuropeptide b had some relaxant effects on the isolated rat strip. These neuropeptides might be involved in down-regulating the host's defensive reaction. |
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| Keywords: | Ixodes sinensis synganglia neuropeptide antinociceptive relaxant effect |
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