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| Infection of SARS-CoV on juvenile and adult Brandt’s vole Microtus brandtii | |
| 作者姓名： | GAOHong PENGJingpian DENGWei SHIDazhao BAOLinlin WANGDehua ZHANGBinglin QINChuan ZHANGZhibin |
| 作者单位： | [1]InstituteofLaboratoryAnimalsScience,ChineseAcademyofMedicalSciences＆PekingUnionMedicalCollege,Beijing100021,China [2]StateKeyLaboratoryofIntegratedManagementonPestInsectsandRodents,StateKeyLaboratoryofReproductiveBiology,InstituteofZoology,ChineseAcademyofSciences,Beijing100080,China [3]ChineseAgriculturalUniversity,Beijing100094,China |
| 摘 要： | We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt‘s Vole (Microtus brandtii) by nasal cavity spraying method (CCIDso is 10^5.7). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt‘s vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt‘s vole may be a potential animal model for SARS research. |
| 关 键 词： | SARS 非典型肺炎 动物模型 流行性传染病 |
| 收稿时间： | 2004-11-09 |
Infection of SARS-CoV on juvenile and adult Brandt’s voleMicrotus brandtii |
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| GAOHong PENGJingpian DENGWei SHIDazhao BAOLinlin WANGDehua ZHANGBinglin QINChuan ZHANGZhibin.Infection of SARS-CoV on juvenile and adult Brandt’s voleMicrotus brandtii[J].Chinese Science Bulletin,2005,50(12):1199-1204. | |
| Authors: | Hong Gao Jingpian Peng Wei Deng Dazhao Shi Linlin Bao Dehua Wang Binglin Zhang Chuan Qin Zhibin Zhang |
| Institution: | 1. Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021, Beijing, China 2. State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080, Beijing, China 3. Chinese Agricultural University, 100094, Beijing, China |
| Abstract: | We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt’s Vole (Microtus brandtii) by nasal cavity spraying method (CCID50 is 105.7). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt’s vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt’s vole may be a potential animal model for SARS research. |
| Keywords: | SARS-CoV animal model pneumonia Brandt’s vole |
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