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Establishment of a high-throughput screening system for universal anti-HIV targets |
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| Authors: | Qi Yin DaoMing Zhuang YaQin Jiang ChuanKe Zhao Xin Zeng ShiYou Li |
| Institution: | 1 Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China; 2 Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; 3 State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China |
| Abstract: | The process of identifying novel human immunodeficiency virus 1 (HIV-1) inhibitors presents a challenge for industrial and scientific research.Virus-cell-based screening approaches offer some advantages in the quest for novel inhibitors because they include multiple targets in a single screen and in some cases reveal targets not captured in biochemical assays.In this study,a high-throughput screening (HTS) system for HIV-1 inhibitors was developed,which allows the simultaneous screening of all the HIV-1 tar... |
| Keywords: | HIV-1 high-throughput screening inhibitor virus-cell-based assay |
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